H2256
骆驼蓬灵
别名:
1-甲基-7-甲氧基-3,4-二氢-β-咔啉, 3,4-二氢骆驼蓬碱, 7-甲氧基-1-甲基-4,9-二氢-3H-吡啶并[3,4-b]吲哚, O-甲基骆驼蓬酚
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关于此项目
经验公式（希尔记法）:
C13H14N2O
化学文摘社编号:
分子量:
214.26
EC Number:
206-152-6
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
207310
MDL number:
InChI key
RERZNCLIYCABFS-UHFFFAOYSA-N
InChI
1S/C13H14N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-4,7,15H,5-6H2,1-2H3
SMILES string
COc1ccc2c3CCN=C(C)c3[nH]c2c1
mp
232-234 °C (lit.)
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Application
Reactant for preparation of:
Natural product scaffold in preparation of:
- Acylated harmalines via Friedel-Crafts reaction
- Phenacyl derivatives of 1-methyl-7-methoxy-β-carbolines as central nervous system affectors
- Palladium harmaline DMSO chloro complex as anti-tumor agent
Natural product scaffold in preparation of:
- Trypanothione reductase inhibitors†
Biochem/physiol Actions
中枢神经系统兴奋剂；可通过 NMDA 受体起作用
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - STOT SE 2
target_organs
Central nervous system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
W Du et al.
Brain research, 770(1-2), 26-29 (1998-01-24)
Harmaline, a beta-carboline derivative, is known to produce tremor through a direct activation of cells in the inferior olive. However, the receptor(s) through which harmaline acts remains unknown. It was recently reported that the tremorogenic actions of harmaline could be
Pervin K Iseri et al.
Neuropharmacology, 61(4), 715-723 (2011-06-07)
Essential tremor (ET) is one of the most common and most disabling movement disorders among adults. The drug treatment of ET remains unsatisfactory. Additional therapies are required for patients with inadequate response or intolerable side effects. The current study aims
Fatta B Nahab et al.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 9(3), 635-638 (2012-03-29)
Recent work exploring the use of high-molecular weight alcohols to treat essential tremor (ET) has identified octanoic acid as a potential novel tremor-suppressing agent. We used an established harmaline-based mouse model of ET to compare tremor suppression by 1-octanol and
Muhammad Rizwan-ul-Haq et al.
Chemosphere, 85(6), 995-1001 (2011-07-26)
Apolipophorin III, traditionally known for lipid transport in insects is fairly established as toxicity indicator against harmaline and tea saponin during this study. Apolipophorin III expressed in the hemolymph and midgut tissues of 3rd, 4th, 5th larval instars and pupae
Screening of medicinal plants from Iranian traditional medicine for acetylcholinesterase inhibition.
Hamid-Reza Adhami et al.
Phytotherapy research : PTR, 25(8), 1148-1152 (2011-02-03)
To find new herbal compounds with an acetylcholinesterase (AChE) inhibitory effect, this study focused on herbal drugs and resins which have been used in Iranian traditional medicine for the treatment of cognitive disorders. Forty drugs were selected from authoritative written
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