H3288
HEMADO
≥99% (HPLC), solid
别名:
2-(1-Hexynyl)-N6-methyladenosine
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关于此项目
经验公式（希尔记法）:
C17H23N5O4
化学文摘社编号:
分子量:
361.40
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
assay
≥99% (HPLC)
form
solid
color
white
solubility
DMSO: 16 mg/mL
storage temp.
2-8°C
SMILES string
CCCCC#Cc1nc(NC)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1
InChI
1S/C17H23N5O4/c1-3-4-5-6-7-11-20-15(18-2)12-16(21-11)22(9-19-12)17-14(25)13(24)10(8-23)26-17/h9-10,13-14,17,23-25H,3-5,8H2,1-2H3,(H,18,20,21)/t10-,13-,14-,17-/m1/s1
InChI key
KOCIMZNSNPOGOP-IWCJZZDYSA-N
Biochem/physiol Actions
A3 adenosine receptor agonist
Rosaria Volpini et al.
Journal of medicinal chemistry, 45(15), 3271-3279 (2002-07-12)
A series of N(6)-alkyl-2-alkynyl derivatives of adenosine (Ado) have been synthesized and evaluated for their affinity at human A(1), A(2A), and A(3) receptors and for their potency at A(2B) adenosine receptor subtypes. The corresponding 2-(1-alkynyl) derivatives of 5'-N-ethylcarboxamidoadenosine (NECA) and
Kerry Barkan et al.
Scientific reports, 10(1), 20781-20781 (2020-11-29)
The adenosine A3 receptor (A3R) belongs to a family of four adenosine receptor (AR) subtypes which all play distinct roles throughout the body. A3R antagonists have been described as potential treatments for numerous diseases including asthma. Given the similarity between
Leigh A Stoddart et al.
British journal of pharmacology, 171(16), 3827-3844 (2014-04-23)
The highly conserved tryptophan (W6.48) in transmembrane domain 6 of GPCRs has been shown to play a central role in forming an active conformation in response to agonist binding. We set out to characterize the effect of this mutation on
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