H3661
4′-羟基双氯芬酸
≥98% (HPLC)
别名:
2-((2,6-二氯-4-羟基苯基)氨基)苯乙酸, 4′-羟基双氯灭痛
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C14H11Cl2NO3
化学文摘社编号:
分子量:
312.15
UNSPSC Code:
12161501
NACRES:
NA.47
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
4198042
General description
4′-羟基双氯芬酸是一种重要的醋氯芬酸代谢物，主要存在于大鼠中。它是尿液中的重要氧化代谢物。
双氯芬酸的 CYP2C9 代谢物。
Application
4′-羟基双氯芬酸已被用于考察龙胆苦甙 (GE) 对人细胞色素P450酶的体外作用。它还被用作酶标记物，用于研究其在不同体外肝脏模型中的代谢活性。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Metabolism of Drugs and Other Xenobiotics (2012)
Metabolic profiling of human long-term liver models and hepatic clearance predictions from in vitro data using nonlinear mixed-effects modeling
Kratochwil NA, et al.
The AAPS Journal, 19(2), 534-550 (2017)
In vitro inhibition and induction of human liver cytochrome P450 enzymes by gentiopicroside: potent effect on CYP2A6
Deng Y, et al.
Drug Metabolism and Pharmacokinetics (2013)
Lu Liu et al.
Pharmaceutical biology, 55(1), 1868-1874 (2017-06-16)
Dihydromyricetin (DHM) is the most abundant and active flavonoid component isolated from Ampelopsis grossedentata (Hand-Mazz) W.T. Wang (Vitaceae) and it possesses numerous pharmacological activities. However, whether DHM affects the activity of human liver cytochrome P450 (CYP) enzymes remains unclear. The
Baodong Ding et al.
Xenobiotica; the fate of foreign compounds in biological systems, 50(8), 913-918 (2020-02-07)
Pachymic acid is a wildly used traditional Chinese medicine with various pharmacological features. It also exists in many drugs which are wildly used in pediatric.The effect of pachymic acid on the activity of eight major CYP isoforms was investigated in
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持