H4512
氢氯噻嗪
drug standard, 1.0 mg/mL in methanol
别名:
6-氯-3,4-二氢-2H-1,2,4-苯并噻二嗪-7-磺酰胺1,1-二氧化物, 6-氯-7-磺酰胺-3,4-二氢-1,2,4-苯并噻二嗪-1,1-二氧化物
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关于此项目
经验公式（希尔记法）:
C7H8ClN3O4S2
化学文摘社编号:
分子量:
297.74
UNSPSC Code:
41116107
PubChem Substance ID:
EC Number:
200-659-6
MDL number:
InChI key
JZUFKLXOESDKRF-UHFFFAOYSA-N
InChI
1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)
SMILES string
NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1Cl
grade
drug standard
assay
≥98%
concentration
1.0 mg/mL in methanol
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
format
single component solution
storage temp.
2-8°C
Gene Information
human ... CA1(759), CA4(762), SLC12A3(6559)
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Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
碳酸酐酶抑制剂
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - STOT SE 1
target_organs
Eyes,Central nervous system
存储类别
3 - Flammable liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
新产品
此项目有
Biopharmaceutical studies of thiazide diuretics. II. High-performance liquid chromatographic method for determination of hydrochlorothiazide in plasma, urine, blood cells and bile.
M Yamazaki et al.
Chemical & pharmaceutical bulletin, 32(6), 2387-2394 (1984-06-01)
A Dornhorst et al.
Lancet (London, England), 1(8421), 123-126 (1985-01-19)
14 hypertensive men with type II diabetes sequentially received, in random order, hydrochlorothiazide 50 mg twice a day, propranolol 80 mg twice a day, and both drugs in combination. The 3-week treatment periods were separated by a 1-week washout period.
Michael A Weber et al.
Lancet (London, England), 381(9866), 537-545 (2012-12-12)
In previous clinical trials in high-risk hypertensive patients, paradoxically higher cardiovascular event rates have been reported in patients of normal weight compared with obese individuals. As a prespecified analysis of the Avoiding Cardiovascular Events through Combination Therapy in Patients Living
P A Tisdall et al.
Clinical chemistry, 26(6), 702-706 (1980-05-01)
We describe a liquid-chromatographic procedure for detection in urine of all thiazide drugs currently used clinically. Urine is treated initially with NaBH4 to convert any chlorothiazide present to hydrochlorothiazide. The urine is acidified with NaH2PO4 (1.0 mol/L, pH 5), and
C Serradeil-Le Gal et al.
The Journal of clinical investigation, 98(12), 2729-2738 (1996-12-15)
SR 121463A, a potent and selective, orally active, nonpeptide vasopressin V2 receptor antagonist, has been characterized in several in vitro and in vivo models. This compound displayed highly competitive and selective affinity for V2 receptors in rat, bovine and human
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