H5257
Hispidin
synthetic (organic), ≥98% (HPLC), protein kinase Cβ, solid
别名:
6-(3,4-dihydroxystyrl)-4-hydroxy-2-pyrone
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关于此项目
经验公式（希尔记法）:
C13H10O5
化学文摘社编号:
分子量:
246.22
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Hispidin, solid, ≥98% (HPLC)
biological source
synthetic (organic)
Quality Level
assay
≥98% (HPLC)
form
solid
storage condition
protect from light
color
yellow to brown
mp
237.5-238.5 °C
solubility
DMSO: >10 mg/mL
storage temp.
−20°C
SMILES string
OC1=CC(/C=C/C(O2)=CC(O)=CC2=O)=CC=C1O
InChI
1S/C13H10O5/c14-9-6-10(18-13(17)7-9)3-1-8-2-4-11(15)12(16)5-8/h1-7,14-16H/b3-1+
InChI key
SGJNQVTUYXCBKH-HNQUOIGGSA-N
Gene Information
human ... PRKACB(5567), PRKAR2B(5577), PRKCB(5579)
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General description
Hispidin is a phenolic compound, that is obtained from a medicinal mushroom, Phellinus linteus.
Biochem/physiol Actions
Hispidin exhibits robust antioxidant, anticancer and antidiabetic properties. It has the ability to guard against peroxynitrite-mediated cytotoxicity, DNA damage and the development of hydroxyl radicals.
Potent inhibitor of protein kinase Cβ, cytotoxic for cancer cells.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available
ppe
Eyeshields, Gloves, type N95 (US)
Sirosh M Bokhari et al.
The Journal of investigative dermatology, 126(2), 460-467 (2005-12-24)
Activation of protein kinase C (PKC) induces phenotypic changes in the morphology of microvascular endothelial cells that affect major functions of the microvasculature. These functions include the first stages of sprouting in angiogenesis, cell migration following wounding, and vascular permeability.
Prabodh Risal et al.
Journal of natural products, 75(10), 1683-1689 (2012-10-03)
In this study the protective effects of davallialactone (1), isolated from Inonotus xeranticus, have been examined against carbon tetrachloride (CCl₄-induced acute liver injury. Mice received subcutaneous injection of 1 (2.5, 5, and 10 mg/kg) for three days before CCl₄ injection
Fungal Light Emitter: Understanding Its Chemical Nature and pH-Dependent Emission in Water Solution.
Cristina García-Iriepa et al.
The Journal of organic chemistry, 85(8), 5503-5510 (2020-03-24)
Fungal bioluminescence is a fascinating natural process, standing out for the continuous conversion of chemical energy into light. The structure of fungal oxyluciferin (light emitter) was proposed in 2017, being different and more complex than other oxyluciferins. The complexity of
C Gonindard et al.
Cell biology and toxicology, 13(3), 141-153 (1997-03-01)
The trypanocidal activity of naturally occurring 6-(3,4-dihydroxystyryl)-4-hydroxy-2-pyrone (hispidin) prompted us to examine its cytotoxic activity toward normal and cancerous cells in culture. Hispidin synthesized in our laboratory to a high degree of purity (checked by 1H and 13C NMR spectroscopy)
Guan-Jhong Huang et al.
Journal of agricultural and food chemistry, 59(10), 5702-5706 (2011-04-02)
The inhibitory activity from the isolated component of the fruiting body Phellinus merrillii (PM) was evaluated against α-glucosidase and lens aldose reductase from Sprague-Dawley male rats and compared to the quercetin as an aldose reductase inhibitor and acarbose as an
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| 货号 | GTIN |
|---|---|
| H5257-5MG | 04061833798027 |
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