H5257
Hispidin
synthetic (organic), ≥98% (HPLC), protein kinase Cβ, solid
别名:
6-(3,4-dihydroxystyrl)-4-hydroxy-2-pyrone
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关于此项目
经验公式（希尔记法）:
C13H10O5
化学文摘社编号:
分子量:
246.22
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
Hispidin, solid, ≥98% (HPLC)
生物来源
synthetic (organic)
质量水平
方案
≥98% (HPLC)
表单
solid
储存条件
protect from light
颜色
yellow to brown
mp
237.5-238.5 °C
溶解性
DMSO: >10 mg/mL
储存温度
−20°C
SMILES字符串
OC1=CC(/C=C/C(O2)=CC(O)=CC2=O)=CC=C1O
InChI
1S/C13H10O5/c14-9-6-10(18-13(17)7-9)3-1-8-2-4-11(15)12(16)5-8/h1-7,14-16H/b3-1+
InChI key
SGJNQVTUYXCBKH-HNQUOIGGSA-N
基因信息
human ... PRKACB(5567), PRKAR2B(5577), PRKCB(5579)
一般描述
Hispidin is a phenolic compound, that is obtained from a medicinal mushroom, Phellinus linteus.
生化/生理作用
Hispidin exhibits robust antioxidant, anticancer and antidiabetic properties. It has the ability to guard against peroxynitrite-mediated cytotoxicity, DNA damage and the development of hydroxyl radicals.
Potent inhibitor of protein kinase Cβ, cytotoxic for cancer cells.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
No data available
闪点(°C)
No data available
个人防护装备
Eyeshields, Gloves, type N95 (US)
Sirosh M Bokhari et al.
The Journal of investigative dermatology, 126(2), 460-467 (2005-12-24)
Activation of protein kinase C (PKC) induces phenotypic changes in the morphology of microvascular endothelial cells that affect major functions of the microvasculature. These functions include the first stages of sprouting in angiogenesis, cell migration following wounding, and vascular permeability.
Prabodh Risal et al.
Journal of natural products, 75(10), 1683-1689 (2012-10-03)
In this study the protective effects of davallialactone (1), isolated from Inonotus xeranticus, have been examined against carbon tetrachloride (CCl₄-induced acute liver injury. Mice received subcutaneous injection of 1 (2.5, 5, and 10 mg/kg) for three days before CCl₄ injection
Wei Chen et al.
Chemico-biological interactions, 199(3), 137-142 (2012-07-24)
Oxidative stress plays an important role in the progression of many chronic diseases including cardiovascular diseases, diabetes, cancer and neurodegenerative disorders. One such mediator of oxidative stress is peroxynitrite, which is highly toxic to cultured neurons and astrocytes, and has
Fungal Light Emitter: Understanding Its Chemical Nature and pH-Dependent Emission in Water Solution.
Cristina García-Iriepa et al.
The Journal of organic chemistry, 85(8), 5503-5510 (2020-03-24)
Fungal bioluminescence is a fascinating natural process, standing out for the continuous conversion of chemical energy into light. The structure of fungal oxyluciferin (light emitter) was proposed in 2017, being different and more complex than other oxyluciferins. The complexity of
Alvaro Macias et al.
International journal of molecular sciences, 22(3) (2021-02-13)
KV1.5 channel function is modified by different regulatory subunits. KVβ1.3 subunits assemble with KV1.5 channels and induce a fast and incomplete inactivation. Inhibition of PKC abolishes the KVβ1.3-induced fast inactivation, decreases the amplitude of the current KV1.5-KVβ1.3 and modifies their
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Datasheet
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