H5257
Hispidin
synthetic (organic), ≥98% (HPLC), protein kinase Cβ, solid
别名:
6-(3,4-dihydroxystyrl)-4-hydroxy-2-pyrone
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关于此项目
经验公式（希尔记法）:
C13H10O5
化学文摘社编号:
分子量:
246.22
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Hispidin, solid, ≥98% (HPLC)
SMILES string
OC1=CC(/C=C/C(O2)=CC(O)=CC2=O)=CC=C1O
InChI key
SGJNQVTUYXCBKH-HNQUOIGGSA-N
InChI
1S/C13H10O5/c14-9-6-10(18-13(17)7-9)3-1-8-2-4-11(15)12(16)5-8/h1-7,14-16H/b3-1+
biological source
synthetic (organic)
assay
≥98% (HPLC)
form
solid
storage condition
protect from light
color
yellow to brown
mp
237.5-238.5 °C
solubility
DMSO: >10 mg/mL
storage temp.
−20°C
Quality Level
Gene Information
human ... PRKACB(5567), PRKAR2B(5577), PRKCB(5579)
Biochem/physiol Actions
Hispidin exhibits robust antioxidant, anticancer and antidiabetic properties. It has the ability to guard against peroxynitrite-mediated cytotoxicity, DNA damage and the development of hydroxyl radicals.
Potent inhibitor of protein kinase Cβ, cytotoxic for cancer cells.
General description
Hispidin is a phenolic compound, that is obtained from a medicinal mushroom, Phellinus linteus.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available
ppe
Eyeshields, Gloves, type N95 (US)
C Gonindard et al.
Cell biology and toxicology, 13(3), 141-153 (1997-03-01)
The trypanocidal activity of naturally occurring 6-(3,4-dihydroxystyryl)-4-hydroxy-2-pyrone (hispidin) prompted us to examine its cytotoxic activity toward normal and cancerous cells in culture. Hispidin synthesized in our laboratory to a high degree of purity (checked by 1H and 13C NMR spectroscopy)
Fungal Light Emitter: Understanding Its Chemical Nature and pH-Dependent Emission in Water Solution.
Cristina García-Iriepa et al.
The Journal of organic chemistry, 85(8), 5503-5510 (2020-03-24)
Fungal bioluminescence is a fascinating natural process, standing out for the continuous conversion of chemical energy into light. The structure of fungal oxyluciferin (light emitter) was proposed in 2017, being different and more complex than other oxyluciferins. The complexity of
Guan-Jhong Huang et al.
Journal of agricultural and food chemistry, 59(10), 5702-5706 (2011-04-02)
The inhibitory activity from the isolated component of the fruiting body Phellinus merrillii (PM) was evaluated against α-glucosidase and lens aldose reductase from Sprague-Dawley male rats and compared to the quercetin as an aldose reductase inhibitor and acarbose as an
Wei Chen et al.
Chemico-biological interactions, 199(3), 137-142 (2012-07-24)
Oxidative stress plays an important role in the progression of many chronic diseases including cardiovascular diseases, diabetes, cancer and neurodegenerative disorders. One such mediator of oxidative stress is peroxynitrite, which is highly toxic to cultured neurons and astrocytes, and has
Alvaro Macias et al.
International journal of molecular sciences, 22(3) (2021-02-13)
KV1.5 channel function is modified by different regulatory subunits. KVβ1.3 subunits assemble with KV1.5 channels and induce a fast and incomplete inactivation. Inhibition of PKC abolishes the KVβ1.3-induced fast inactivation, decreases the amplitude of the current KV1.5-KVβ1.3 and modifies their
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