H7287
Anti-Heat Shock Protein 110 (HD-19) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-Hsp110
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 110 kDa
种属反应性
mouse, rat
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 2-4 μg/mL using rat cerebellum
microarray: suitable
western blot: 0.5-1 μg/mL using cytosolic fraction of rat brain and whole cell extract of mouse fibroblast NIH3T3 cell line
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
mouse ... Hsph1(15505)
一般描述
Heat shock protein 110 (Hsp110) belongs to a family of large stress proteins referred to as the SSE family. This protein is a normal constituent of mammalian cells, ubiquitously expressed but at higher levels in the brain.
免疫原
synthetic peptide located at the C-terminus of mouse Hsp110 (amino acids 840-858), conjugated to KLH.
应用
Anti-Heat Shock Protein 110 (HD-19) antibody produced in rabbit may be used in immunoblotting and immunohistochemistry.
生化/生理作用
Anti-Heat Shock Protein 110 (Hsp110) (HD-19) recognizes Hsp110 (110 kDa, may appear as a doublet band in some cell/tissue extracts).
Heat shock protein 110 (Hsp110) is associated with the nucleoli of non-stressed and heat-stressed murine cells. Overexpression of Hsp110 gene has been shown to confer cellular heat resistance to prevent protein aggregation and to keep denatured protein in a folding-competent state. HSP110 plays a role in the pathophysiology of brain damage such as ischemia/reperfusion injuries and pathological conditions such as Alzheimer′s disease.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
制备说明
For continuous use, store at 2-8 °C for up to one month. For prolonged storage, freeze in working aliquots at −20 °C. Repeated freezing and thawing is not recommended. Storage in frost-free freezers is also not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Binnur Eroglu et al.
Molecular and cellular biology, 30(19), 4626-4643 (2010-08-04)
Accumulation of tau into neurofibrillary tangles is a pathological consequence of Alzheimer's disease and other tauopathies. Failures of the quality control mechanisms by the heat shock proteins (Hsps) positively correlate with the appearance of such neurodegenerative diseases. However, in vivo
B L Hylander et al.
Brain research, 869(1-2), 49-55 (2000-06-24)
Hsp110 is one of the few, major heat shock proteins of mammalian cells and was one of the earliest heat shock proteins described. However, it has only recently been cloned and studied at the molecular level. It has been noted
H J Oh et al.
The Journal of biological chemistry, 272(50), 31636-31640 (1998-02-12)
The 110-kDa heat shock protein (hsp110) has long been recognized as one of the primary heat shock proteins in mammalian cells. It belongs to a recently described protein family that is a significantly diverged subgroup of the hsp70 family and
D P Easton et al.
Cell stress & chaperones, 5(4), 276-290 (2000-10-26)
Both the Grp170 and Hsp110 families represent relatively conserved and distinct sets of stress proteins, within a more diverse category that also includes the Hsp70s. All of these families are found in a wide variety of organisms from yeasts to
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