产品名称
L-高丝氨酸内酯 盐酸盐,
form
powder
Quality Level
technique(s)
ligand binding assay: suitable
color
white
storage temp.
−20°C
SMILES string
Cl.N[C@H]1CCOC1=O
InChI
1S/C4H7NO2.ClH/c5-3-1-2-7-4(3)6;/h3H,1-2,5H2;1H/t3-;/m0./s1
InChI key
XBKCXPRYTLOQKS-DFWYDOINSA-N
General description
L-高丝氨酸内酯（HSL），也称为酰化-HSL，由高丝氨酸内酯环和脂肪酰基侧组成。 细菌中的酰基-HSL水平取决于底物和酰化-高丝氨酸内酯合酶的可用性。
Application
L-高丝氨酸内酯盐酸盐已被用作动脉平滑肌收缩的抑制剂。
Biochem/physiol Actions
L-高丝氨酸内酯抑制能够减少毒力因子并阻止炎症和组织损伤。 在铜绿假单胞菌（Pseudomonas aeruginosa）中，它能够控制毒力因子产生和生物膜形成。在根癌农杆菌（ Agrobacterium tumefaciens）中，它是接合转移的必需成分。
酰化L-高丝氨酸内酯被用于研究细菌群体感应信号传导机制。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Inhibiting N-acyl-homoserine lactone synthesis and quenching Pseudomonas quinolone quorum sensing to attenuate virulence
Chan KG, et al.
Frontiers in Microbiology, 6, 1173-1173 (2015)
Nathan A Ahlgren et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(17), 7183-7188 (2011-04-08)
Many Proteobacteria possess LuxI-LuxR-type quorum-sensing systems that produce and detect fatty acyl-homoserine lactone (HSL) signals. The photoheterotroph Rhodopseudomonas palustris is unusual in that it produces and detects an aryl-HSL, p-coumaroyl-HSL, and signal production requires an exogenous source of p-coumarate. A
Long-chain acyl-homoserine lactone quorum-sensing regulation of Rhodobacter capsulatus gene transfer agent production
Schaefer AL, et al.
Journal of Bacteriology, 184(23), 6515-6521 (2002)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| H7890-1G | 04061826059791 |
| H7890-250MG | 04061833804827 |