H9252
金丝桃素 来源于贯叶连翘
≥85% (HPLC), powder
别名:
4,5,7,4′,5′,7′-六羟基-2,2′-二甲基萘并二蒽酮, Cyclo werrol, 金丝桃红
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经验公式（希尔记法）:
C30H16O8
化学文摘社编号:
分子量:
504.44
EC Number:
208-941-0
UNSPSC Code:
12352202
MDL number:
Beilstein/REAXYS Number:
1917913
assay
≥85% (HPLC)
form
powder
color
black
solubility
1 M NaOH: 10 mg/mL, ethanol: 5 mg/mL (with sonication), DMSO: soluble
SMILES string
Cc1cc(O)c2C(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6C(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c56
InChI
1S/C30H16O8/c1-7-3-9(31)19-23-15(7)16-8(2)4-10(32)20-24(16)28-26-18(12(34)6-14(36)22(26)30(20)38)17-11(33)5-13(35)21(29(19)37)25(17)27(23)28/h3-6,31-36H,1-2H3
InChI key
BTXNYTINYBABQR-UHFFFAOYSA-N
Biochem/physiol Actions
圣约翰麦芽汁中的蒽醌衍生物对革兰阳性和阴性菌均有效。
法规信息
新产品
此项目有
Martin-Pierre Sauviat et al.
Journal of natural products, 70(4), 510-514 (2007-02-13)
The effects and the mode of action of hypericin (1) were studied, in the dark, on the action potential (AP) and the L-type Ca2+ channel of frog atrial heart muscle, using intracellular microelectrode and patch-clamp techniques, respectively. In the presence
Souvik Kusari et al.
Journal of natural products, 72(10), 1825-1835 (2009-09-15)
The possible microbial mechanism of hypericin (1) and emodin (2) biosynthesis was studied in axenic submerged culture conditions in the endophytic fungus Thielavia subthermophila, isolated from Hypericum perforatum. The growth and secondary metabolite production of the endophyte remained independent of
Souvik Kusari et al.
Journal of natural products, 71(2), 159-162 (2008-01-29)
For the first time, an endophytic fungus has been isolated from the stems of the medicinal herb Hypericum perforatum (St. John's Wort). The fungus produced the napthodianthrone derivative hypericin ( 1) in rich mycological medium (potato dextrose broth) under shake
Veronika Huntosova et al.
International journal of pharmaceutics, 436(1-2), 463-471 (2012-07-21)
Low-density lipoproteins (LDL), a natural in vivo carrier of cholesterol in the vascular system, play a key role in the delivery of hydrophobic/amphiphilic photosensitizers to tumor cells in photodynamic therapy of cancer. To make this delivery system even more efficient
Malini Olivo et al.
Annals of biomedical engineering, 40(2), 460-473 (2011-11-30)
Photosensitizers (PSs) have shown great potentials as molecular contrast agents in photodynamic diagnosis (PDD) of cancer. While the diagnostic values of PSs have been proven previously, little efforts have been put into developing optical imaging and diagnostic algorithms. In this
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