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H9285

Heat Shock Factor 1 human

Name: Heat Shock Factor 1 human
Brand: SIGMA

recombinant, expressed in E. coli, ~65% (SDS-PAGE), solution

别名:

HSF-1, Heat Shock Transcription Factor 1

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关于此项目

UNSPSC Code:

12352204

MDL number:

MFCD01866935

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属性

biological source

human

recombinant

expressed in E. coli

form

solution

concentration

~65% (SDS-PAGE)

UniProt accession no.

Q00613

storage temp.

−20°C

Gene Information

human ... HSF1(3297)

说明

Biochem/physiol Actions

A transcriptional factor that mediates the expression of heat shock proteins by binding to a heat shock response element located upstream from the heat shock protein genes. In unstressed cells HSF-1 is non-DNA binding protein that rapidly converts to the transcriptionally active form in response to heat and heavy metals.

Physical form

in 25 mM Tris pH 8.0, 150 mM NaCl, 2 mM DTT

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分析证书(COA)

Lot/Batch Number

081K1299

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Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress.

K D Sarge et al.

Molecular and cellular biology, 13(3), 1392-1407 (1993-03-01)

The existence of multiple heat shock factor (HSF) genes in higher eukaryotes has promoted questions regarding the functions of these HSF family members, especially with respect to the stress response. To address these questions, we have used polyclonal antisera raised