H9521
15-羟基二十碳-5Z,8Z,11Z,13E-四烯酸
~100 μg/mL in ethanol, ≥95%
别名:
15(S)-HPETE
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关于此项目
经验公式（希尔记法）:
C20H32O4
化学文摘社编号:
分子量:
336.47
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
200-578-6
MDL number:
assay
≥95%
concentration
~100 μg/mL in ethanol
shipped in
dry ice
storage temp.
−70°C
SMILES string
CCCCC[C@H](OO)\C=C\C=C/C\C=C/C\C=C/CCCC(O)=O
InChI
1S/C20H32O4/c1-2-3-13-16-19(24-23)17-14-11-9-7-5-4-6-8-10-12-15-18-20(21)22/h4-5,8-11,14,17,19,23H,2-3,6-7,12-13,15-16,18H2,1H3,(H,21,22)/b5-4-,10-8-,11-9-,17-14+/t19-/m0/s1
InChI key
BFWYTORDSFIVKP-VAEKSGALSA-N
Packaging
在氩气下包装。
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2
存储类别
3 - Flammable liquids
wgk
WGK 1
flash_point_f
57.2 °F - closed cup
flash_point_c
14 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
危险化学品
此项目有
Suraneni V K Mahipal et al.
Biochemical pharmacology, 74(2), 202-214 (2007-05-23)
Growth inhibitory effects of 15-lipoxygenase-1 [13-(S)-HPODE and 13-(S)-HODE] and 15-lipoxygenase-2 [15-(S)-HPETE and 15-(S)-HETE] (15-LOX-1 and LOX-2) metabolites and the underlying mechanisms were studied on chronic myeloid leukemia cell line (K-562). The hydroperoxy metabolites, 15-(S)-HPETE and 13-(S)-HPODE rapidly inhibited the growth
Judith V Ferrante et al.
Journal of immunology (Baltimore, Md. : 1950), 174(6), 3169-3172 (2005-03-08)
The metabolism of arachidonic acid via the lipoxygenase and cyclooxygenase pathways generates metabolites that regulate the inflammatory response. Although products of lipoxygenase are classically proinflammatory, recently it has been demonstrated that lipoxins, 15-hydroperoxyeicosatetraenoic acid (15-HPETE) and 15-hydroxyeicosatetraenoic acid exhibit anti-inflammatory
Oscar A Bizzozero et al.
Neurochemical research, 32(12), 2114-2122 (2007-06-07)
In this study, we investigated the possible link between lipid peroxidation (LPO) and the formation of protein carbonyls (PCOs) during depletion of brain glutathione (GSH). To this end, rat brain slices were incubated with the GSH depletor diethyl maleate (DEM)
Michelle V Williams et al.
Rapid communications in mass spectrometry : RCM, 19(6), 849-858 (2005-02-22)
Reactive oxygen species convert the omega-6 polyunsaturated fatty acid arachidonic acid into 15-hydroperoxy-5,8,11,13-(Z,Z,ZE)-eicosatetraenoic acid (15-HPETE). Cyclooxygenases and lipoxygenases can also convert arachidonic acid into 15-HPETE. Vitamin C mediated decomposition of 15(S)-HPETE to protein- and DNA-reactive bifunctional electrophiles was examined by
Gang Wu et al.
Biochemistry, 46(2), 534-542 (2007-01-11)
Prostaglandin H synthase-1 (PGHS-1) is a bifunctional heme protein catalyzing both a peroxidase reaction, in which peroxides are converted to alcohols, and a cyclooxygenase reaction, in which arachidonic acid is converted into prostaglandin G2. Reaction of PGHS-1 with peroxide forms
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