Haptoglobin Human, Phenotype 2-2

Haptoglobin is an α₂-globulin found in normal plasma at a concentration of 82-236 mg/dl and accounts for 0.4-2.6% of the total plasma proteins. . The monomeric form of this acute phase plasma protein is composed of four polypeptide chains: two α chains and two β chains.

Haptoglobin is an acute phase protein that scavenges hemoglobin released into the circulation. Haptoglobin, the plasma protein with highest binding affinity to hemoglobin, is mainly expressed in the liver.

Haptoglobin was used to study haptoglobin expression and release by rabbit oviduct and endometrium. It was also used to analyze its localization in blastocyst extra-embryonic matrix and fluid during pre-implantation.

Occurs as 3 major phenotypes: type 1-1, type 2-1, type 2-2.