product line
MISSION®
form
solid
mature sequence
UGAGGUAGUAGUUUGUGCUGUU
Sanger mature/minor accession no.
Sanger microRNA accession no.
storage temp.
−20°C
Gene Information
—
General description
即用型MISSION miRNA模拟物是小的双链RNA分子，旨在模拟导入细胞时的内源性成熟miRNA分子。已知miRNA以多种方式调节基因表达，包括翻译抑制，mRNA裂解和去腺苷酸化。MISSION miRNA模拟物是MISSION RNAi产品家族的成员，为miRNA研究人员提供了一系列选择，从单个MISSION Mimics到基于最新版本miRBase的完整人类miRNA 模拟物库（目前由曼彻斯特大学主办，以前由桑格研究所主办）。
- 优化并准备进行转染。
- 新型MISSION miRNA模拟设计已在功能上测试了针对天然miRNA靶标的敲低效率。
- 独特的MISSION miRNA模拟设计显著降低了可能的有义链脱靶效应。
- 可作为整个人类文库和单个miRNA靶标获得。
Biochem/physiol Actions
The miRNA hsa-let-7i-5p is associated with colorectal cancer metastasis. Its targets include TRIM41 (tripartite motif-containing protein 41), SOX13 (SRY (sex determining region Y)-box 13), SLC25A4 (solute carrier family 25 member 4), SEMA4F (semaphorin-4F), RPUSD2 (RNA pseudouridylate synthase domain-containing protein 2), PLEKHG6 (pleckstrin homology domain-containing family G member 6), CCND2 (G1/S-specific cyclin-D2) and BTBD3 (BTB/POZ domain-containing protein 3). It also targets TLR4 (toll like receptor) and can inhibit TLR4-mediated damage.
Other Notes
miRBase V18 Mature ID update: hsa-let-7i-5p
Legal Information
MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
相关内容
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| HMI0021-5NMOL | 04061831380507 |