product line
MISSION®
form
solid
mature sequence
AGCUACAUCUGGCUACUGGGU
Sanger mature/minor accession no.
Sanger microRNA accession no.
storage temp.
−20°C
Gene Information
—
General description
即用型MISSION miRNA模拟物是小的双链RNA分子，旨在模拟导入细胞时的内源性成熟miRNA分子。已知miRNA以多种方式调节基因表达，包括翻译抑制，mRNA裂解和去腺苷酸化。MISSION miRNA模拟物是MISSION RNAi产品家族的成员，为miRNA研究人员提供了一系列选择，从单个MISSION Mimics到基于最新版本miRBase的完整人类miRNA 模拟物库（目前由曼彻斯特大学主办，以前由桑格研究所主办）。
- 优化并准备进行转染。
- 新型MISSION miRNA模拟设计已在功能上测试了针对天然miRNA靶标的敲低效率。
- 独特的MISSION miRNA模拟设计显著降低了可能的有义链脱靶效应。
- 可作为整个人类文库和单个miRNA靶标获得。
Application
MISSION® microRNA Mimic (hsa-miR-222) has been used to study the effect of specific miRNAs on macrophage-derived apoptotic bodies-mediated proliferation of the recipient epithelial cells.
Biochem/physiol Actions
The microRNA hsa-miR-222 (also referred to as hsa-miR-222-3p) targets SOCS3 (suppressor of cytokine signaling 3) and ZFPM2 (zinc finger protein). It is present in the ovarian cancer derived-exosomes and is proposed as a biomarker for diagnosis. Exosomal miR-222-3p is associated with the polarization of tumor-associated macrophages. Also, hsa-miR-222 is downregulated in the plasma of patients with ventricular septal defect.
Other Notes
miRBase V18 Mature ID update: hsa-miR-222-3p
Legal Information
MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
相关内容
Characterization of circulating microRNA expression in patients with a ventricular septal defect.
Li D, et al.
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| HMI0400-5NMOL | 04061831382426 |