MISSION^® microRNA Mimic

即用型MISSION miRNA模拟物是小的双链RNA分子，旨在模拟导入细胞时的内源性成熟miRNA分子。已知miRNA以多种方式调节基因表达，包括翻译抑制，mRNA裂解和去腺苷酸化。MISSION miRNA模拟物是MISSION RNAi产品家族的成员，为miRNA研究人员提供了一系列选择，从单个MISSION Mimics到基于最新版本miRBase的完整人类miRNA 模拟物库（目前由曼彻斯特大学主办，以前由桑格研究所主办）。

• 优化并准备进行转染。
• 新型MISSION miRNA模拟设计已在功能上测试了针对天然miRNA靶标的敲低效率。
• 独特的MISSION miRNA模拟设计显著降低了可能的有义链脱靶效应。
• 可作为整个人类文库和单个miRNA靶标获得。

The microRNA hsa-miR-675 (also referred to as hsa-miR-675-5p) is present in H19, a long non coding RNA. It is mainly involved in carcinogenesis. This miRNA is downregulated in non-small cell lung cancer (NSCLC) and is associated with tumor progression and development. It works as a tumor suppressor in NSCLC by targeting GPR55 (G-protein coupled receptor 55). The hsa-miR-675 is upregulated in colon cancer and helps in hypoxia-mediated epithelial to mesenchymal transition. It targets ZEB1 (zinc finger E-box-binding homeobox 1) at the post-transcriptional level and controls the progression of pancreatic cancer cells. It also has an oncogenic role in esophageal squamous cell carcinoma by targeting REPS2 (RalBP1-associated Eps domain-containing protein 2).

miRBase V18 Mature ID update: hsa-miR-675-5p

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany