Anti-HNRNPA1 antibody produced in rabbit

HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1) functions in mRNA metabolism. It shuttles continuously between nucleus and cytoplasm and functions in several processes such as mRNA export, internal ribosome entry site (IRES)-mediated translation and mRNA stability. In humans, it acts as an auxiliary factor for the processing of a specific miRNA substrate by binding specifically to pri-miR-18a, the stem-loop precursor of miR-18a and regulating its Drosha-mediated processing. Defects in this gene are associated with multisystem proteinopathy and ALS (Amyotrophic lateral sclerosis 20). An alternatively spliced isoform of this protein is capable of controlling the splicing and replication of human immunodeficiency virus (HIV)-1.

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All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1) is a ribonucleoprotein, which functions as an RNA-binding protein. It can interact with both RNA and DNA, through its two nucleic acid-binding domains. It is proteolytically cleaved into a 196-amino acid protein called UP1 (unwinding protein 1). This protein retains the two parent nucleic acid-binding domains. It is one of the major RNA-binding proteins, and though it localizes to nucleus, it can shuttle to cytoplasm as well.

heterogeneous nuclear ribonucleoprotein A1 recombinant protein epitope signature tag (PrEST)

Corresponding Antigen APREST74297

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

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