Anti-IFI6 antibody produced in rabbit

IFI6 (interferon, α-inducible protein 6) is a part of ISG12 (IFN stimulated gene) family. In humans, there are four members in this family, where IFI6 is located at chromosome 1p35, and the other three at 14q32. It is a hydrophobic protein with a molecular weight of 12.9kDa. It has a conserved ISG12 motif, which is made of ~80 amino acids. When expressed ectopically, IFI6 is found to be localized to mitochondria.

Interferon alpha-inducible protein 6 precursor recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

The functional characteristics of IFI6 (interferon, α-inducible protein 6) is not yet well known. This protein is induced by interferons (IFN), and is responsible for cell survival. It is strongly induced by IFN-α2b, where it prevents apoptosis and maintains mitochondrial stability. This way, it also antagonizes the apoptotic effect of TRAIL, especially in tumor cells. Thus, it can be a potential therapeutic target for various malignancies, such as myeloma. IFI6 is also induced by estrogen, and is highly expressed in the initial stages of breast cancer. It alters the balance between pro- and anti-apoptotic members of Bcl-2 family. Hence, it plays a role in poor prognosis of breast cancer, hyperplasia and tamoxifen resistance.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Corresponding Antigen APREST86654.

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.