Anti-NTRK2 antibody produced in rabbit

NTRK2 (neurotrophic tyrosine kinase, receptor, type 2) gene is mapped to human chromosome 9q22.1 and spans a length of 353kb. It consists of 21 exons that are arranged in six different blocks. This protein is composed of the promoter region, the extracellular domain and the juxtamembrane region, intracellular juxtamembane domain, followed by the tyrosine kinsase domain. The C-terminus of the tyrosine kinase domain and a γ phospholipase C binding site are encoded by exons 20 and 21.

BDNF/NT-3 growth factors receptor precursor recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

NTRK2 (neurotrophic tyrosine kinase, receptor, type 2) gene encodes a membrane-bound receptor belonging to the neurotrophic tyrosine receptor kinase (NTRK) family. It undergoes autophosphorylation on binding to neurotrophin and phosphorylates the members of MAPK pathway. NTRK2 is expressed in hypothalamic neurons that are involved in the control of food intake and energy expenditure. Polymorphism in this gene is linked to eating disorders leading to obesity. It regulates short- and long-term synaptic function and neural plasticity along with its ligand brain-derived neurotropic factor. Alterations in this gene can cause major depressive disorder (MDD).

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Corresponding Antigen APREST71430

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.