Anti-LMBRD1 antibody produced in rabbit

LMBRD1 (LMBR1 domain containing 1) is an integral lysosomal membrane protein located on chromosome 6q13. It is expressed in human liver tissue, and it comprises a putative actin-binding site and a bipartite nuclear localization signal.

Probable lysosomal cobalamin transporter recombinant protein epitope signature tag (PrEST)

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)

LMBRD1 (LMBR1 domain containing 1) may be involved in the lysosomal cobalamin transport. It was found to mediate transport of cobalamin through the lysosomal membranes. Mutation in LMBRD1 gene causes the cblF (Cobalamin F defect) defect of vitamin B₁₂ (cobalamin) metabolism, characterized with accumulation of internalized free cobalamin in the lysosome.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Corresponding Antigen APREST73290

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