biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
product line
Prestige Antibodies® Powered by Atlas Antibodies
form
buffered aqueous glycerol solution
species reactivity
human
technique(s)
immunohistochemistry: 1:20- 1:50
immunogen sequence
APPRLICDSRVLERYLLEAKEAENITTGCAEHCSLNENITVPD
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... EPO(2056)
General description
The gene EPO (erythropoietin) is mapped to human chromosome 7q22. In fetal cells, EPO protein is generated by the liver cells and in adults, it is produced mainly by the kidney cells. EPO is a low-molecular-weight glycoprotein hormone and a hypoxia responsive cytokine.
Immunogen
erythropoietin recombinant protein epitope signature tag (PrEST)
Application
All Prestige Antibodies®Powered by Atlas Antibodies is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
Anti-EPO antibody produced in rabbit has been used in immunohistochemistry.
Anti-EPO antibody produced in rabbit has been used in immunohistochemistry.
Biochem/physiol Actions
EPO (erythropoietin) is mainly involved in erythropoiesis (controls red blood cell volume), but also has role in angiogenesis and tissue protection. Its concentration increases in conditions, such as anemia, hypoxia, renal hypoperfusion or EPO-associated hepatoprotective signaling.
Features and Benefits
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
Physical form
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
Other Notes
Corresponding Antigen APREST78083.
Legal Information
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
A Case of Erythropoietin Producing a Large Hepatocellular Carcinoma
with Advanced Erythrocytosis
with Advanced Erythrocytosis
Irei T, et al.
The Japanese Society of Gastroenterological Surgery, 47, 18-18 (2014)
Chromosome 7 long arm deletion in myeloid disorders: a narrow breakpoint region in 7q22 defined by molecular mapping.
Kere J, et al.
Blood, 73, 230-234 (1989)
Hepatic erythropoietin response in cirrhosis. A contemporary review.
Ris?r LM, et al.
Scandinavian Journal of Clinical and Laboratory Investigation, 76, 183-189 (2016)