I0529
Anti-Interleukin-16 antibody produced in goat
affinity isolated antibody, lyophilized powder
别名:
Anti-IL-16
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), WB
Citations:
3
biological source
goat
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
human
technique(s)
indirect ELISA: 0.5-1.0 μg/mL, western blot: 0.1-0.2 μg/mL
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... IL16(3603)
General description
Interleukin-16 is also known as lymphocyte chemoattractant factor (LCF) and acts as chemoattractant for human T cells. IL-16 is secreted by cells of immune system such as T cells, dendritic cells and eosinophils. It is also secreted by the non-immune cells such as endothelial cells, fibroblasts and neurons. IL-16 is biologically active in the multimeric form and binds to CD4 and CCR5 receptors. The signaling induced by IL-16 activates pathways that involve MAPK, PI3K and SAPK. The biological activities of IL-16 are important for inflammation, migration, cell cycle progression, cell proliferation, development of Th1 cells and regulation of T cell responses. IL-16 signaling is important in the pathophysiology of Crohn′s disease, HIV infection, airway inflammation in asthma and rheumatoid arthritis. Anti-Interleukin-16 antibody recognizes human IL-16.
Immunogen
recombinant human IL-16 expressed in E. coli.
Application
Anti-Interleukin-16 antibody may be used for immunoblotting at a working antibody concentration of 0.1-0.2 μg/ml. For ELISA, a working concentration of 0.5-1.0 μg/ml is recommended.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
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存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Monocytes or T cells in Crohn's disease: does IL-16 allow both to play at that game?
S Schreiber
Gut, 49(6), 747-748 (2001-11-16)
W W Cruikshank et al.
Journal of leukocyte biology, 67(6), 757-766 (2000-06-17)
Interleukin 16 (IL-16) was initially described in 1982 as the first T cell chemoattractant. Through interaction with CD4, IL-16 has now been characterized as a chemoattractant for a variety of CD4+ immune cells. Recent in vivo studies have more fully
Interleukin-16 in asthma.
Jing-min Deng et al.
Chinese medical journal, 119(12), 1017-1025 (2006-06-30)
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