I1029
Interleukin-2 Soluble Receptor γ human
>97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder
别名:
IL-2 sRγ
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关于此项目
Biological source:
human
Recombinant:
expressed in baculovirus infected Sf21 cells
Assay:
>97% (SDS-PAGE)
Form:
lyophilized powder
Mol wt:
40 kDa
Impurities:
endotoxin, tested
biological source
human
recombinant
expressed in baculovirus infected Sf21 cells
assay
>97% (SDS-PAGE)
form
lyophilized powder
potency
1.979 μg/mL ED50
mol wt
40 kDa
packaging
pkg of 50 μg
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... IL2RG(3561)
General description
IL2RG (Interleukin-2 soluble receptor γ) is a type I transmembrane glycoprotein. It is a component of interleukin (IL)-receptors, including IL-2, IL-7, IL-9, IL-15 and IL-21.
Biochem/physiol Actions
IL2RG (Interleukin-2 soluble receptor γ) controls JAK3 (Janus kinase 3) signalling in ligand-dependent manner. Expression of IL2RG mRNA is upregulated in peripheral blood of humans suffering from schizophrenia. Mutations in IL2RG are associated with X-linked severe combined immunodeficiency, due to disturbances in function of cytokine receptors.
Recombinant human IL-2 soluble receptor γ is a member of the hematopoietin receptor family and is required for IL-2 receptor signaling.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 2.5 mg bovine serum albumin.
Analysis Note
The bioactivity is measured by its ability to inhibit the IL-2-dependent proliferation of a human megakaryocytic leukemic cell line, MO7e, in the presence of 30 μg/ml of soluble IL-2 Rγ.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Taco W Kuijpers et al.
Haematologica, 98(7), 1030-1038 (2013-02-14)
Mutations in the common gamma chain (γc, CD132, encoded by the IL2RG gene) can lead to B(+)T(-)NK(-) X-linked severe combined immunodeficiency, as a consequence of unresponsiveness to γc-cytokines such as interleukins-2, -7 and -15. Hypomorphic mutations in CD132 may cause
A Agarwal et al.
Oncogene, 34(23), 2991-2999 (2014-08-12)
To understand the role of cytokine and growth factor receptor-mediated signaling in leukemia pathogenesis, we designed a functional RNA interference (RNAi) screen targeting 188 cytokine and growth factor receptors that we found highly expressed in primary leukemia specimens. Using this
Hovsep Ghazaryan et al.
Psychiatry research, 217(3), 158-162 (2014-04-10)
Altered immune response, including low-grade inflammatory processes, is involved in the pathogenesis of schizophrenia, a chronic psychiatric disorder with complex etiology. Distinct gene variants of a number of pro-inflammatory and chemotactic cytokines together with their receptors associate with this disorder.
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Datasheet
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