I1392
HA-100
别名:
1-(5-Isoquinolinesulfonyl)piperazine hydrochloride
生化/生理作用
Inhibitor of PKA, PKC and myosin light chain kinase.
分析说明
Actual content given on the label
HCl content may vary.
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
M Awazu et al.
Journal of cardiovascular pharmacology, 17 Suppl 7, S500-S502 (1991-01-01)
The vasoconstrictor response is defective in diabetes mellitus (DM). Activation of protein kinase C (PKC) is also known to prevail in diabetes mellitus, and it is thought to be secondary to abnormal diacylglycerol metabolism. To ascertain whether this PKC activation
Regulation of neutrophil chemotaxis: correlations with actin polymerization.
L Harvath
Cancer investigation, 8(6), 651-654 (1990-01-01)
J T O'Flaherty et al.
Biochemical and biophysical research communications, 163(3), 1456-1460 (1989-09-29)
Three protein kinase C blockers (staurosporin, Cl, and sphinganine) acted temperature- and time-dependently on human neutrophils to lower the affinity and number of high affinity plasmalemma receptors available to leukotriene B4. The drugs did not alter the ligand's binding to
S Daniels et al.
Comparative biochemistry and physiology. Comparative physiology, 105(4), 659-665 (1993-08-01)
1. The standard O2-paradox has been studied in the Langendorff-perfused rat heart. 2. Perfusion of glucose-free saline under anoxia did not cause release of creatine kinase (CK) although, it is suggested, there was a progressive rise in [Ca2+]i. 3. Ca(2+)-depletion
L Harvath et al.
Journal of immunology (Baltimore, Md. : 1950), 139(9), 3055-3061 (1987-11-01)
The protein kinase inhibitor, 1-(5-isoquinolinesulfonyl) piperazine (C-I), inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol, without inhibiting superoxide release from PMN stimulated with the chemoattractants C5a or N-formyl-methionyl-leucyl-phenylalanine (f-Met-Leu-Phe). In this study, we
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