I1392
HA-100
别名:
1-(5-Isoquinolinesulfonyl)piperazine hydrochloride
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关于此项目
经验公式（希尔记法）:
C13H15N3O2S
化学文摘社编号:
分子量:
277.34
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
SMILES string
Cl.O=S(=O)(N1CCNCC1)c2cccc3cnccc23
storage temp.
−20°C
Gene Information
human ... MYLK(4638), MYLK2(85366)
Biochem/physiol Actions
Inhibitor of PKA, PKC and myosin light chain kinase.
Analysis Note
Actual content given on the label
HCl content may vary.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Regulation of neutrophil chemotaxis: correlations with actin polymerization.
L Harvath
Cancer investigation, 8(6), 651-654 (1990-01-01)
M Awazu et al.
Journal of cardiovascular pharmacology, 17 Suppl 7, S500-S502 (1991-01-01)
The vasoconstrictor response is defective in diabetes mellitus (DM). Activation of protein kinase C (PKC) is also known to prevail in diabetes mellitus, and it is thought to be secondary to abnormal diacylglycerol metabolism. To ascertain whether this PKC activation
J T O'Flaherty et al.
Biochemical and biophysical research communications, 163(3), 1456-1460 (1989-09-29)
Three protein kinase C blockers (staurosporin, Cl, and sphinganine) acted temperature- and time-dependently on human neutrophils to lower the affinity and number of high affinity plasmalemma receptors available to leukotriene B4. The drugs did not alter the ligand's binding to
L Harvath et al.
Journal of immunology (Baltimore, Md. : 1950), 139(9), 3055-3061 (1987-11-01)
The protein kinase inhibitor, 1-(5-isoquinolinesulfonyl) piperazine (C-I), inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol, without inhibiting superoxide release from PMN stimulated with the chemoattractants C5a or N-formyl-methionyl-leucyl-phenylalanine (f-Met-Leu-Phe). In this study, we
D A Bass et al.
The Journal of biological chemistry, 262(14), 6643-6649 (1987-05-15)
Preincubation of neutrophils with certain agonists may "prime" the cells to cause increased responses to a second stimulus ("primed stimulation"). We used two approaches to examine the role of protein kinase C (Ca2+/phospholipid-dependent enzyme) in priming and stimulation by 1-oleoyl-2-acetylglycerol
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