重组
expressed in HEK 293 cells
方案
≥98% (SDS-PAGE)
表单
lyophilized powder
效能
≤4 ng/mL ED50
分子量
15 kDa (glycosylated)
技术
cell culture | mammalian: suitable
适用性
endotoxin tested
储存温度
−20°C
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一般描述
Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. It is a monomeric glycoprotein and proinflammatory cytokine, and contains four-a-helix bundles in its structure. IL-2 gene is mapped to human chromosome 4q27. Recombinant human IL-2 is expressed in human 293 cells as a glycoprotein with a calculated molecular mass of 15 kDa. This protein is manufactured in human cells using an all-human production system, with full chemically defined ingredients and with no serum. The human cells expression system allows human-like glycosylation and folding, and often supports better stability of the protein in culture.
生化/生理作用
白细胞介素-2（IL-2）是由某些T淋巴细胞亚群产生的免疫调节因子。该淋巴因子能够促进活化T细胞和相关细胞类型的长期生长。IL-2在NK细胞的激活和增殖、诱导γ-干扰素和B细胞生长因子分泌中发挥作用，并且能够调节IL-2受体的表达。
Interleukin-2 (IL-2) is a lymphokine that promotes the long-term proliferation of activated T cells and acts as an essential mediator of the immune response. IL-2 signals through the IL-2 receptor, majorly via the IL-2Ra subunit. IL-2 signaling via IL-2/anti-IL-2 immune complexes aids immune surveillance improvement during suppressed immunity. It also effectively controls infection. IL-2 plays a role in the activation and proliferation of natural killer (NK) cells, induces γ-inter-feron and B cell growth factor secretion and modulates the expression of the IL-2 receptor. It also elicits anti-tumor immunity. An elevated expression level of IL-2 along with other interleukins is observed in colorectal cancer.
外形
Supplied as a lyophilized powder containing phosphate buffered saline.
分析说明
The biological activity of recombinant human IL-2 was tested in culture by measuring its ability to stimulate proliferation of the mouse CTLL-2 cells (mouse cytotoxic T cell line).
其他说明
APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT
危险声明
预防措施声明
危险分类
Aquatic Chronic 3
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
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