Anti-phospho-Insulin Receptor/Insulin-Like Growth Factor-1 Receptor (pTyr¹¹⁵⁸/^1162/1163) antibody produced in rabbit

Insulin-like growth factors -1 and -2 are important regulators of signalling that mediates growth and metabolism in cells. Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver. IGF-1 acts via specific receptor, IGF-1R, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, Raf/Ras and PI3K cascades. IGF 1R is fully activated by phosphorylation of tyrosine residues at Tyr¹¹⁵⁸, Tyr¹¹⁶² and Tyr¹¹⁶³. The effect of IGF-1 is by endocrine, paracrine and autocrine signalling. The effects of IGF-1R signalling are important at many developmental levels from cells to organ to organism, growth, differentiation, anti-apoptosis, proliferation and transformation. Irregular IGF-1 signaling has been implicated in many cancers including melanoma, breast, lung, colon and prostate
Anti-phospho-IR/IGF1R (pTyr¹¹⁵⁸/¹¹⁶²/¹¹⁶³) specifically recognizes human receptor and insulin-like growth factor-1 receptor phosphorylated at tyrosines 1158, 1162 and 1163. It may cross react with mouse and rat IR/IGF1R (100% homology).

synthetic phosphopeptide derived from the region of IR that contains tyrosines 1158, 1162, and 1163.

Anti-phospho-IR/IGF1R (pTyr¹¹⁵⁸/¹¹⁶²/¹¹⁶³) antibody may be used for immunoblotting at a working concentration of 0.1-1.0 μg/ml using whole cell lysates from CHO-T cells.

Solution in Dulbecco′s phosphate buffered saline, pH 7.3, containing 50% glycerol, 1 mg/mL BSA (IgG and protease-free) and 0.05% sodium azide.

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