I2409
伊莫福新
≥97% (NMR), semisolid (waxy)
别名:
1-Hexadecylmercapto-2-methoxymethyl-3-propyl phosphoric acid monocholine ester, BM 41.440
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关于此项目
经验公式（希尔记法）:
C26H56NO5PS
化学文摘社编号:
分子量:
525.77
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
产品名称
伊莫福新, ≥97% (NMR), semisolid (waxy)
InChI key
ODEDPKNSRBCSDO-UHFFFAOYSA-N
SMILES string
CCCCCCCCCCCCCCCCSCC(COC)COP([O-])(=O)OCC[N+](C)(C)C
InChI
1S/C26H56NO5PS/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22-34-25-26(23-30-5)24-32-33(28,29)31-21-20-27(2,3)4/h26H,6-25H2,1-5H3
assay
≥97% (NMR)
form
semisolid (waxy)
solubility
H2O: 10 mg/mL
originator
Roche
storage temp.
−20°C
Biochem/physiol Actions
Protein Kinase C (PKC) inhibitor; an ether lipid derivative of lysophosphatidylcholine has antineoplastic activity in vitro and in vivo. IC50 = 560 nM. Competitive at the regulatory site of PKC. Ilmofosine is active against a variety of explanted human non-small cell lung, breast, colorectal, ovarian, renal cell cancer, and melanoma tumors in vitro at concentrations of 1-30 μg/mL.
Protein Kinase C (PKC) inhibitor; an ether lipid derivative of lysophosphatidylcholine has antineoplastic activity.
Features and Benefits
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Packaging
Air-sensitive, sealed under nitrogen
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Z Kiss et al.
FEBS letters, 412(2), 313-317 (1997-07-28)
The antineoplastic alkyl lysophospholipids (ALP) 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3) and 1-S-hexadecylthio-2-methoxymethyl-2-deoxy-rac-glycero-3-phosphocho line (BM41.440) were found to alter phospholipase D (PLD)-mediated phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) hydrolysis in NIH 3T3 fibroblasts. After a shorter (50 min) treatment, 2.5-7.5 microg/ml concentrations of ALP stimulated
R Girgert et al.
Journal of cancer research and clinical oncology, 121(5), 262-266 (1995-01-01)
The thioether lysophospholipid BM 41.440 proved to be toxic against cells of two neuroblastoma cell lines in a dose- and time-dependent manner. The ID50 estimated in three different in vitro test systems declined from about 10 micrograms/ml after 24 h
J Hofmann et al.
British journal of cancer, 76(7), 862-869 (1997-01-01)
The thioether phospholipid ilmofosine (BM 41 440) is a new anti-cancer drug presently undergoing phase II clinical trials. Because resistance to anti-tumour drugs is a major problem in cancer treatment, we investigated the resistance of different cell lines to this
D Berkovic et al.
European journal of cancer (Oxford, England : 1990), 33(11), 1875-1880 (1998-02-21)
Hexadecylphosphocholine (HePC) is a new etherphospholipid derived substance with pronounced antineoplastic activity. So far the mode of action of this compound has not been resolved. Therefore, we decided to approach this problem by generating HePC resistant sublines of susceptible cells.
S Azzouz et al.
Parasite (Paris, France), 16(3), 215-221 (2009-10-21)
We studied the stress proteins induced in protozoa Leishmania donovani after treatment with edelfosine, miltefosine and ilmofosine. We studied the morphological and structural modifications caused in the promastigote forms of the parasite after treatment with the three alkyl-lysophospholipids (ALPs). A
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