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Merck
CN

I2784

INH2BP

≥98% (HPLC), solid

别名:

5-Iodo-6-amino-1,2-benzopyrone

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关于此项目

经验公式（希尔记法）:
C9H6INO2
化学文摘社编号:
137881-27-7
分子量:
287.05
UNSPSC Code:
12352202
PubChem Substance ID:
24724511
MDL number:
MFCD00912555

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InChI

1S/C9H6INO2/c10-9-5-1-4-8(12)13-7(5)3-2-6(9)11/h1-4H,11H2

SMILES string

Nc1ccc2OC(=O)C=Cc2c1I

InChI key

WWRAFPGUBABZSD-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

solubility

DMSO: soluble 31 mg/mL, H2O: insoluble

storage temp.

2-8°C

Biochem/physiol Actions

Inhibitor of poly (ADP-ribose) polymerase-1 (PARP-1); anti-apoptotic.

存储类别

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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分析证书(COA)

Lot/Batch Number
035K4713

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C Szabó et al.
Proceedings of the National Academy of Sciences of the United States of America, 95(7), 3867-3872 (1998-05-09)
Peroxynitrite, a cytotoxic oxidant formed from nitric oxide (NO) and superoxide, induces DNA strand breakage, which activates the nuclear enzyme poly(ADP-ribose) synthase (PARS; EC 2.4.2.30). The cellular function of PARS was determined in fibroblast lines from PARS knockout animals (PARS-/-)
Raquel M Forsythe et al.
Shock (Augusta, Ga.), 17(3), 180-184 (2002-03-20)
Studies indicate that endotoxin (LPS) causes intestinal injury, increases inducible nitric oxide synthase (iNOS) activity, leads to increased NO production, and promotes bacterial translocation (BT). To investigate the mechanism by which LPS causes gut injury and to test the hypothesis
G S Scott et al.
Journal of neuroimmunology, 117(1-2), 78-86 (2001-06-30)
Peroxynitrite formation has been demonstrated during experimental allergic encephalomyelitis (EAE). Furthermore, peroxynitrite has been identified as an activator of poly(ADP-ribose) synthetase (PARS), an enzyme implicated in neurotoxicity. In the current study, we examined the role of PARS activation in the
Lina Du et al.
The Journal of biological chemistry, 278(20), 18426-18433 (2003-03-11)
Poly(ADP-ribosylation), primarily via poly(ADP-ribose) polymerase-1 (PARP-1), is a pluripotent cellular process important for maintenance of genomic integrity and RNA transcription in cells. However, during conditions of oxidative stress and energy depletion, poly(ADP-ribosylation) paradoxically contributes to mitochondrial failure and cell death.
France Vaillancourt et al.
Arthritis research & therapy, 10(5), R107-R107 (2008-09-11)
4-Hydroxynonenal (HNE) is one of the most abundant and reactive aldehydes of lipid peroxidation products and exerts various effects on intracellular and extracellular signalling cascades. We have previously shown that HNE at low concentrations could be considered as an important
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