I2784
INH2BP
≥98% (HPLC), solid
别名:
5-Iodo-6-amino-1,2-benzopyrone
方案
≥98% (HPLC)
表单
solid
溶解性
DMSO: soluble 31 mg/mL
H2O: insoluble
储存温度
2-8°C
SMILES字符串
Nc1ccc2OC(=O)C=Cc2c1I
InChI
1S/C9H6INO2/c10-9-5-1-4-8(12)13-7(5)3-2-6(9)11/h1-4H,11H2
InChI key
WWRAFPGUBABZSD-UHFFFAOYSA-N
生化/生理作用
Inhibitor of poly (ADP-ribose) polymerase-1 (PARP-1); anti-apoptotic.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
C Szabó et al.
Proceedings of the National Academy of Sciences of the United States of America, 95(7), 3867-3872 (1998-05-09)
Peroxynitrite, a cytotoxic oxidant formed from nitric oxide (NO) and superoxide, induces DNA strand breakage, which activates the nuclear enzyme poly(ADP-ribose) synthase (PARS; EC 2.4.2.30). The cellular function of PARS was determined in fibroblast lines from PARS knockout animals (PARS-/-)
Raquel M Forsythe et al.
Shock (Augusta, Ga.), 17(3), 180-184 (2002-03-20)
Studies indicate that endotoxin (LPS) causes intestinal injury, increases inducible nitric oxide synthase (iNOS) activity, leads to increased NO production, and promotes bacterial translocation (BT). To investigate the mechanism by which LPS causes gut injury and to test the hypothesis
P I Bauer et al.
Biochimie, 77(5), 374-377 (1995-01-01)
A non-covalently binding inhibitory ligand of poly(ADP-ribose) polymerase, 5-iodo-6-amino-1,2-benzopyrone, when incubated at 5-600 microM external concentration with an E-ras-transformed tumorigenic cell line or with human prostatic carcinoma cells for 40 to 60 days converts both cancer cells to a non-tumorigenic
G S Scott et al.
Journal of neuroimmunology, 117(1-2), 78-86 (2001-06-30)
Peroxynitrite formation has been demonstrated during experimental allergic encephalomyelitis (EAE). Furthermore, peroxynitrite has been identified as an activator of poly(ADP-ribose) synthetase (PARS), an enzyme implicated in neurotoxicity. In the current study, we examined the role of PARS activation in the
Lina Du et al.
The Journal of biological chemistry, 278(20), 18426-18433 (2003-03-11)
Poly(ADP-ribosylation), primarily via poly(ADP-ribose) polymerase-1 (PARP-1), is a pluripotent cellular process important for maintenance of genomic integrity and RNA transcription in cells. However, during conditions of oxidative stress and energy depletion, poly(ADP-ribosylation) paradoxically contributes to mitochondrial failure and cell death.
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