I4153
Anti-Interleukin-12 Receptor β1 antibody produced in goat
affinity isolated antibody, lyophilized powder
别名:
Anti-IL-12 Receptor β1
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关于此项目
UNSPSC Code:
51111800
MDL number:
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), WB
Citations:
5
biological source
goat
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
human
technique(s)
indirect ELISA: 0.5-1.0 μg/mL using recombinant human IL-12 Rβ1, western blot: 0.1-0.2 μg/mL using recombinant human IL-12 Rβ1
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... IL12RB1(3594)
General description
IL-12 also known as Natural Killer Cell Stimulatory Factor (NKSF) is a 75kD protein that belongs to type I cytokine receptor family and is produced mainly by monocytes and NK cells. IL-12 signals with the help of IL-12 receptor made up of two subunits designated β1 and β2. Interleukin-12 receptor subunit β-1 binds interleukin-12 with low affinity and facilitates in IL12 transduction. Anti-interleukin-12 receptor β1 antibody can be used in ELISA (0.5-1.0 μg/mL) using recombinant human IL-12 Rβ1. Goat anti-interleukin-12 receptor β1 antibody has shown 5% (approx.) cross-reactivity with recombinant mouse IL-12 Rβ1.
Immunogen
recombinant human IL-12 Rβ1 extracellular domain, expressed in NSO cells
Application
Anti-interleukin-12 receptor β1 antibody can be used in immunoblotting for localization and detection of recombinant human IL-12 Rβ1.
Biochem/physiol Actions
The antibody shows 5% cross-reactivity with recombinant mouse IL-12 Rβ1.
Physical form
Lyophilized from 0.2 μm filtered solution of phosphate buffered saline
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Interleukin-12
Storkus, W.J, et al
The Cytokine Handbook, 391-425 (1998)
A O Chua et al.
Journal of immunology (Baltimore, Md. : 1950), 153(1), 128-136 (1994-07-01)
A cDNA encoding a human IL-12R subunit was isolated by expression cloning. This subunit is a 662 amino acid type I transmembrane protein with an extracellular domain of 516 amino acids and a cytoplasmic domain of 91 amino acids. It
D H Presky et al.
Proceedings of the National Academy of Sciences of the United States of America, 93(24), 14002-14007 (1996-11-26)
We have identified a cDNA from a human phytohemagglutinin-activated lymphoblast library encoding a protein that binds 125I-labeled human interleukin 12 (125I-huIL-12) with a Kd of about 5 nM when expressed in COS-7 cells. When coexpressed in COS-7 cells with the
Lu Chen et al.
International journal of oncology, 47(4), 1361-1370 (2015-09-01)
Vasoactive intestinal peptide (VIP) has been regarded as deactivator for macrophages. However, the depressive effect of VIP on tumor-associated macrophages (TAM) has not been recognized. In the present study, we investigated the effect of VIP on gastric cancer via TAM
Christi Parham et al.
Journal of immunology (Baltimore, Md. : 1950), 168(11), 5699-5708 (2002-05-23)
IL-23 is a heterodimeric cytokine composed of the IL-12p40 "soluble receptor" subunit and a novel cytokine-like subunit related to IL-12p35, termed p19. Human and mouse IL-23 exhibit some activities similar to IL-12, but differ in their capacities to stimulate particular
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