Anti-Interleukin-9 antibody produced in goat

Interleukin-9 (IL-9) is a pleotropic cytokine produced by activated T cells and also by mast cells in response to LPS and IL-1. The production of IL-9 is amplified by TGF-β, IL-2 and IL-25. The biological effects of IL-9 are mediated by IL-9 receptor (IL-9R) that is made up of an α and a γ chain. IL-9 signalling results in the activation of major signalling pathways involving STAT1, -3 and -5, MAPK, PI3K and IRS. IL-9 is a pro-inflammatory cytokine and promotes allergic inflammation and airway remodelling in lungs. It also is important in cell growth and differentiation of T cells, B cells, mast cells, hematopoietic progenitors, epithelial cells and airway smooth muscle cells
Anti-Interleukin-9 recognizes mouse IL-9. It does not neutralize the activity of recombinant human IL-9.

recombinant mouse IL-9 expressed in Sf 21 insect cells.

Anti-mouse Interleukin-9 antibody may be used for immunoblotting at a working concentration of 1.0 μg/ml. For ELISA a concentration of 0.5 μg/ml is recommended. The antibody is also suitable for neutralization reactions

The antibody neutralizes the biological activity of recombinant mouse IL-9, but not recombinant human IL-9.

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline

Purified using protein G

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