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一般描述
肌醇(MI,myo-肌醇)是一种糖样分子,主要存在于人脑的神经胶质细胞中。它是C6糖醇的立体异构体,属于肌醇家族的一员。可作为三磷酸肌醇的前体,也可充当胞内第二信使。Myo-肌醇调节多种激素水平,如促甲状腺激素、促卵泡激素(FSH)和胰岛素。Myo-肌醇和d-chiro-肌醇(肌醇的另一种立体异构体)以不同方式平衡胰岛素抵抗(IR)有关的代谢异常。
应用
肌醇已用于:
- 作为气-液相色谱法(GC)单糖分析的标准品
- 作为无R海马培养基的组成部分,用于腹腔巨噬细胞(PMΦ)的培养,以研究细胞糖酵解代谢
- 作为SOFaaci培养基的补充,用于延长体外胚胎生长
- 作为α最低必需培养基(αMEM)完全培养基的组分,用于培养自然杀伤(NK)细胞系
生化/生理作用
肌醇(MI)作为渗透剂,是膜磷酸肌醇和磷脂的重要前体。它有助于形成细胞膜和髓鞘片结构。在阿尔茨海默症、脑胶质瘤病和脑肿瘤等各种脑部疾病中观察到肌醇(MI)浓度增加。
膜磷脂、糖基化磷脂酰肌醇锚定蛋白、磷酸肌醇酯第二信使的成分,其中锚定蛋白可将糖蛋白锚定到细胞膜上。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Hiroki Okada et al.
STAR protocols, 2(3), 100733-100733 (2021-08-31)
Microscopy-based analysis of protein accumulation at a given subcellular location in real time provides invaluable insights into the function of a protein in a specific process. Here, we describe a detailed protocol for determining protein accumulation kinetics at the division
Satu Hänninen et al.
Bio-protocol, 7(9), e2268-e2268 (2017-05-05)
Glycerophospholipids consist of a glycerophosphate backbone to which are esterified two acyl chains and a polar head group. The head group (e.g., choline, ethanolamine, serine or inositol) defines the glycerophospholipid class, while the acyl chains together with the head group
C Servo et al.
Diabetologia, 11(6), 575-580 (1975-12-01)
Cerebrospinal fluid (CSF) or CSF and plasma levels of sorbitol, 1,5-anhydroglucitol and myoinositol of diabetic and non-diabetic patients with normal kidney function and of diabetic and non-diabetic patients with impaired kidney function were measured by gas-liquid chromatography. The CSF sorbitol
Pascal M Groenen et al.
American journal of obstetrics and gynecology, 189(6), 1713-1719 (2004-01-08)
The purpose of this study was to investigate the maternal and children's myo-inositol, glucose, and zinc status in association with spina bifida risk. Sixty-three mothers and 70 children with spina bifida and 102 control mothers and 85 control children were
For Yue Tso et al.
PloS one, 16(3), e0247640-e0247640 (2021-03-05)
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