I5531
IIK7
solid
别名:
N-Butanoyl 2-(9-methoxy-6H-isoindolo[2,1-a]indol-11-yl)ethanamine
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关于此项目
经验公式（希尔记法）:
C22H24N2O2
分子量:
348.44
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C22H24N2O2/c1-3-6-21(25)23-12-11-18-19-13-16(26-2)9-10-20(19)24-14-15-7-4-5-8-17(15)22(18)24/h4-5,7-10,13H,3,6,11-12,14H2,1-2H3,(H,23,25)
SMILES string
CCCC(=O)NCCc1c2-c3ccccc3Cn2c4ccc(OC)cc14
InChI key
RQYIUGOJQFWLAZ-UHFFFAOYSA-N
form
solid
color
white
solubility
DMSO: soluble 30 mg/mL
storage temp.
−20°C
Gene Information
human ... MTNR1A(4543), MTNR1B(4544)
Biochem/physiol Actions
Melatonin receptor agonist
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Francisco Javier Navarro Gil et al.
The Journal of pharmacology and experimental therapeutics, 371(1), 186-190 (2019-08-03)
Melatonin has been shown to enhance tear secretion associated with dinucleotide diadenosine tetraphosphate. This study investigated the isolated action of melatonin and its analogs, agomelatine, N-butanoyl-2-(2-methoxy-6H-isoindolo[2,1-a]indol-11-yl) ethanamine (IIK7), and 5-methoxycarbonylamino-N-cetyltryptamine (5-MCA-NAT) (10 µl at 100 µM), on tear secretion when
Irene Reyes-Resina et al.
Cells, 9(1) (2020-01-16)
Experiments in the late nineties showed an inverse relationship in the eye levels of melatonin and dopamine, thereby constituting an example of eye parameters that are prone to circadian variations. The underlying mechanisms are not known but these relevant molecules
Hanan Awad Alkozi et al.
British journal of pharmacology, 177(9), 2090-2105 (2020-01-05)
Often, glaucoma presents with elevated eye hydrostatic pressure, which is regulated by endogenous melatonin. Phenylephrine increases cytoplasmic [Ca2+ ], via α1 -adrenoceptor activation, that is detrimental in glaucoma. The aims of this study were (a) to elucidate the role of
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