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I6783

Isopimaric Acid

Name: Isopimaric Acid
Brand: SIGMA

≥98% (GC), potassium (BK) channel oepner, powder

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关于此项目

经验公式（希尔记法）:

C₂₀H₃₀O₂

化学文摘社编号:

5835-26-7

分子量:

302.45

UNSPSC Code:

12352106

PubChem Substance ID:

24724518

NACRES:

NA.77

MDL number:

MFCD04113116

Assay:

≥98% (GC)

Form:

powder

Quality level:

100

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属性

产品名称

Isopimaric Acid, ≥98% (GC), powder

Quality Level

100

assay

≥98% (GC)

form

powder

color

white

solubility

DMSO: 25 mg/mL

storage temp.

−20°C

SMILES string

[H][C@]12CC[C@@](C)(CC1=CC[C@@]3([H])[C@@](C)(CCC[C@]23C)C(O)=O)C=C

InChI

1S/C20H30O2/c1-5-18(2)12-9-15-14(13-18)7-8-16-19(15,3)10-6-11-20(16,4)17(21)22/h5,7,15-16H,1,6,8-13H2,2-4H3,(H,21,22)/t15-,16+,18-,19+,20+/m0/s1

InChI key

MXYATHGRPJZBNA-KRFUXDQASA-N

说明

General description

Isopimaric acid, a resin acid produced by conifer trees, is a tricyclic diterpene compound. High levels of isopimaric acid in the hepatocytes of the rainbow trout may impair calcium signalling machinery. Isopimaric acid is a potential big potassium (BK) channel opener.

Biochem/physiol Actions

Potent opener of large conductance calcium activated K⁺ (BK) channels.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

GHS09

signalword

Warning

hcodes

H400

pcodes

P273

Hazard Classifications

Aquatic Acute 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Enzyme cytochemical responses of mussels (Mytilus edulis) to resin acid constituents of pulp mill effluents.

G E Fâhraeus-Van Ree et al.

Bulletin of environmental contamination and toxicology, 63(4), 430-437 (1999-09-29)

A large-conductance (BK) potassium channel subtype affects both growth and mineralization of human osteoblasts.

Neil C Henney et al.

American journal of physiology. Cell physiology, 297(6), C1397-C1408 (2009-09-25)

The pharmacology of the large-conductance K(+) (BK) channel in human osteoblasts is not well defined, and its role in bone is speculative. Here we assess BK channel properties in MG63 cells and primary human osteoblasts and determine whether pharmacological modulation

Isopimaric acid from Pinus nigra shows activity against multidrug-resistant and EMRSA strains of Staphylococcus aureus.

Eileen Smith et al.

Phytotherapy research : PTR, 19(6), 538-542 (2005-08-23)

The diterpene isopimaric acid was extracted from the immature cones of Pinus nigra (Arnold) using bioassay-guided fractionation of a crude hexane extract. Isopimaric acid was assayed against multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA). The minimum inhibitory concentrations (MIC) were

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全球贸易项目编号

货号	GTIN
I6783-5MG	04061833857922
I6783-25MG	04061832961903