I6783
Isopimaric Acid
≥98% (GC), potassium (BK) channel oepner, powder
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关于此项目
经验公式（希尔记法）:
C20H30O2
化学文摘社编号:
分子量:
302.45
MDL编号:
UNSPSC代码:
12352106
PubChem化学物质编号:
NACRES:
NA.77
产品名称
Isopimaric Acid, ≥98% (GC), powder
方案
≥98% (GC)
表单
powder
颜色
white
溶解性
DMSO: 25 mg/mL
储存温度
−20°C
SMILES字符串
[H][C@]12CC[C@@](C)(CC1=CC[C@@]3([H])[C@@](C)(CCC[C@]23C)C(O)=O)C=C
InChI
1S/C20H30O2/c1-5-18(2)12-9-15-14(13-18)7-8-16-19(15,3)10-6-11-20(16,4)17(21)22/h5,7,15-16H,1,6,8-13H2,2-4H3,(H,21,22)/t15-,16+,18-,19+,20+/m0/s1
InChI key
MXYATHGRPJZBNA-KRFUXDQASA-N
相关类别
一般描述
Isopimaric acid, a resin acid produced by conifer trees, is a tricyclic diterpene compound. High levels of isopimaric acid in the hepatocytes of the rainbow trout may impair calcium signalling machinery. Isopimaric acid is a potential big potassium (BK) channel opener.
生化/生理作用
Potent opener of large conductance calcium activated K+ (BK) channels.
特点和优势
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Sohag N Saleh et al.
The Journal of pharmacology and experimental therapeutics, 321(3), 1075-1084 (2007-03-10)
Because chloride (Cl(-)) channel blockers such as niflumic acid enhance large-conductance Ca(2+)-activated potassium channels (BK(Ca)), the aim of this study was to determine whether there is a reciprocal modification of Ca(2+)-activated chloride Cl(-) currents (I(ClCa)) by two selective activators of
Ammanamanchi S R Anjaneyulu et al.
Journal of Asian natural products research, 4(1), 53-61 (2002-05-07)
Chemical examination of the ethyl acetate extract of the roots of Rhizophora mucronata collected from Mangalore Coast resulted in the isolation of three more new diterpenoids, rhizophorins C-E (1-3) in addition to the two, rhizophorin A, (6R,11S,13S)-6,11,13-trihydroxy-2,3-seco-14-labden-2,8-olid-3-oic acid, and rhizophorin
I Christianson-Heiska et al.
Toxicology in vitro : an international journal published in association with BIBRA, 22(3), 589-597 (2008-01-22)
Wood extractives are constituents of wood present in pulp and paper mill effluents, which may cause reproductive disturbances in fish. In the present study, we examined three cellular in vitro bioassays in order to assess (anti)estrogenic potencies of the wood
Molecular basis of pimarane compounds as novel activators of large-conductance Ca2+-activated K+ channel alpha-subunit.
Imaizumi Y, et al.
Molecular Pharmacology, 62(4), 836-846 (2002)
Suresh Awale et al.
Chemical & pharmaceutical bulletin, 51(3), 268-275 (2003-03-04)
From the methanolic extract of Indonesian Orthosiphon stamineus, nine new highly-oxygenated isopimarane-type diterpenes [7-O-deacetylorthosiphol B (1), 6-hydroxyorthosiphol B (2), 3-O-deacetylorthosiphol I (3), 2-O-deacetylorthosiphol J (4), siphonols A-E (5-9)] have been isolated together with nine known diterpenes [orthosiphols H (10), K
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