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Merck
CN

I7146

Ilimaquinone

别名:

3-[(Decahydro-1β,2β,4aβ-trimethyl-5-methylene-1-naphthyl)methyl]-2-hydroxy-5-methoxybenzoquinone

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关于此项目

经验公式(希尔记法):
C22H30O4
化学文摘社编号:
分子量:
358.47
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
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SMILES string

[H][C@@]12CCCC(=C)[C@@]1(C)CC[C@H](C)[C@@]2(C)CC3=C(O)C(=O)C=C(OC)C3=O

storage temp.

−20°C

Biochem/physiol Actions

Induces reversible breakdown of Golgi membranes.

存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

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V Faúndez et al.
The Journal of cell biology, 138(3), 505-515 (1997-08-11)
Carrier vesicle generation from donor membranes typically progresses through a GTP-dependent recruitment of coats to membranes. Here we explore the role of ADP ribosylation factor (ARF) 1, one of the GTP-binding proteins that recruit coats, in the production of neuroendocrine
C Jamora et al.
Cell, 91(5), 617-626 (1997-12-11)
We have previously shown that ilimaquinone (IQ), a marine sponge metabolite, causes complete vesiculation of the Golgi stacks. By reconstituting the IQ-mediated vesiculation of the Golgi apparatus in permeabilized cells, we now demonstrate that this process does not require ARF
P A Feldman et al.
The Journal of membrane biology, 155(3), 275-287 (1997-02-01)
To examine the mechanism(s) and pathways of gap junction formation and removal a novel and reversible inhibitor of protein secretion, ilimaquinone (IQ), was employed. IQ has been reported to cause the vesiculation of Golgi membranes, block protein transport at the
B Veit et al.
The Journal of cell biology, 122(6), 1197-1206 (1993-09-01)
We have recently shown that ilimaquinone (IQ) causes the breakdown of Golgi membranes into small vesicles (VGMs for vesiculated Golgi membranes) and inhibits vesicular protein transport between successive Golgi cisternae (Takizawa et al., 1993). While other intracellular organelles, intermediate filaments
T C Taylor et al.
Molecular biology of the cell, 5(2), 237-252 (1994-02-01)
We investigated the role of ADP-ribosylation factors (ARFs) in Golgi function using biochemical and morphological cell-free assays. An ARF-free cytosol produced from soluble Chinese hamster ovary (CHO) extracts supports intra-Golgi transport by a mechanism that is biochemically indistinguishable from control

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