Anti-Inositol 1,4,5-Triphosphate Receptor (Type II) antibody produced in rabbit

The gene ITPR2 (Inositol 1,4,5-Triphosphate Receptor type 2) encodes type 2 intracellular receptor that binds to Inositol 1,4,5 trisphosphate. The gene encodes a 2701 amino acid protein that contains six membrane-spanning regions near the C-termini. The cytoplasmic N-terminal domain is involved in ligand-binding. The gene is mapped to human chromosome 12p11.

synthetic petide with a sequence derived from the cytoplasmic, amino-terminus of rat IP3R-II.

The receptor encoded by the gene ITPR2 (Inositol 1,4,5-Triphosphate Receptor type 2) is a Ca²⁺ release channel in the endoplasmic reticulum that is stimulated upon binding to its ligand inositol 1,4,5-triphosphate. It mediates intracellular calcium signaling. It facilitates the release of Ca²⁺ from endoplasmic reticulum and modulates intracellular Ca²⁺ concentration. Loss of ITPR2 gene function is found to be associated with anhidrosis and can inhibit sweat production in humans and mice.

Solution in PBS with 1.0 mg/ml bovine serum albumin and 0.05% sodium azide.

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