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Merck
CN

I7903

Sigma-Aldrich

Anti-IKKα (716-734) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

别名:

Anti-IκB Kinase α

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MDL编号:
UNSPSC代码:
12352203
NACRES:
NA.44
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生物来源

rabbit

质量水平

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

表单

buffered aqueous solution

分子量

antigen 85 kDa

种属反应性

human

技术

western blot: 0.5 μg/mL using human HeLa cell extract

UniProt登记号

运输

dry ice

储存温度

−20°C

基因信息

human ... CHUK(1147)

一般描述

IKK α is a component of I-κ-B-kinase (IKK) core complex consisting of IKK α, IKK β and IKK γ and belongs to Ser/Thr protein kinase family. It has a pivotal role in NF-κ-B signaling pathway. Anti-IKK α antibody can be used in immunoblot for detecting IKKα (α subunit of IκB kinase). Rabbit anti-IKK α antibody reacts specifically with IKK α (85kD) and has shown no cross reactivity with IKK β or IKK γ.

免疫原

synthetic peptide corresponding to amino acids 716-734 of human IκB Kinase α (IKKα) (C1).

应用

Anti-IKK α antibody can be used in western blotting (diluted 1:1000) using human HeLa cell extract.

外形

Solution in phosphate buffered saline containing 0.02% sodium azide.

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储存分类代码

10 - Combustible liquids

法规信息

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J A DiDonato et al.
Nature, 388(6642), 548-554 (1997-08-07)
Nuclear transcription factors of the NF-kappaB/Rel family are inhibited by IkappaB proteins, which inactivate NF-kappaB by trapping it in the cell cytoplasm. Phosphorylation of IkappaBs marks them out for destruction, thereby relieving their inhibitory effect on NF-kappaB. A cytokine-activated protein

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