I7903
Anti-IKKα (716-734) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-IκB Kinase α
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 85 kDa
species reactivity
human
technique(s)
western blot: 0.5 μg/mL using human HeLa cell extract
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Quality Level
Gene Information
human ... CHUK(1147)
General description
IKK α is a component of I-κ-B-kinase (IKK) core complex consisting of IKK α, IKK β and IKK γ and belongs to Ser/Thr protein kinase family. It has a pivotal role in NF-κ-B signaling pathway. Anti-IKK α antibody can be used in immunoblot for detecting IKKα (α subunit of IκB kinase). Rabbit anti-IKK α antibody reacts specifically with IKK α (85kD) and has shown no cross reactivity with IKK β or IKK γ.
Immunogen
synthetic peptide corresponding to amino acids 716-734 of human IκB Kinase α (IKKα) (C1).
Application
Anti-IKK α antibody can be used in western blotting (diluted 1:1000) using human HeLa cell extract.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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存储类别
10 - Combustible liquids
法规信息
新产品
此项目有
J A DiDonato et al.
Nature, 388(6642), 548-554 (1997-08-07)
Nuclear transcription factors of the NF-kappaB/Rel family are inhibited by IkappaB proteins, which inactivate NF-kappaB by trapping it in the cell cytoplasm. Phosphorylation of IkappaBs marks them out for destruction, thereby relieving their inhibitory effect on NF-kappaB. A cytokine-activated protein
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