I9266
Insulin Receptor from rat liver
buffered aqueous glycerol solution
生物来源
rat liver
质量水平
表单
buffered aqueous glycerol solution
包装
vial of 250 units
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
rat ... Insr(24954)
应用
Insulin receptor from rat liver has been used in insulin receptor kinase assay.
生化/生理作用
IR (insulin receptor) protein is a heterotetrameric receptor tyrosine kinase having α subunits for ligand binding and β subunits for tyrosine kinase activity. Insulin works thriought IR. IR is present in the cytoplasm and the nucleus.
外形
Solution in 50% glycerol containing 50 mM HEPES, pH 7.6, 150 mM NaCl, and 0.1% Triton.
制备说明
Purified by affinity chromatography on wheat germ agglutinin.
其他说明
One unit will catalyze the incorporation of 1 pmol per min of phosphate from γ-32P-ATP into poly(Glu,Tyr), 4:1, at 30 °C.
储存分类代码
10 - Combustible liquids
WGK
WGK 1
法规信息
新产品
此项目有
Y Zick et al.
The Journal of biological chemistry, 258(1), 75-80 (1983-01-10)
Insulin stimulates phosphorylation of both alpha- and beta- subunits of its own receptor in a cell-free system. A solubilized lectin-purified preparation of insulin receptors from rat liver membranes was preincubated with or without insulin at 4 degrees C and labeled
Maria J Amaya et al.
Hepatology (Baltimore, Md.), 59(1), 274-283 (2013-07-11)
Insulin's metabolic effects in the liver are widely appreciated, but insulin's ability to act as a hepatic mitogen is less well understood. Because the insulin receptor (IR) can traffic to the nucleus, and Ca(2+) signals within the nucleus regulate cell
Stephen A Whelan et al.
The Journal of biological chemistry, 285(8), 5204-5211 (2009-12-19)
Increased O-linked beta-N-acetylglucosamine (O-GlcNAc) is associated with insulin resistance in muscle and adipocytes. Upon insulin treatment of insulin-responsive adipocytes, O-GlcNAcylation of several proteins is increased. Key insulin signaling proteins, including IRS-1, IRS-2, and PDK1, are substrates for OGT, suggesting potential
Zi-Jian Lan et al.
Cellular and molecular life sciences : CMLS, 77(8), 1623-1643 (2019-08-06)
The pathophysiology of type 2 diabetes mellitus (T2D) is characterized by reduced or absent insulin receptor (INSR) responsiveness to its ligand, elevated hepatic glucose output and impaired glucose uptake in peripheral tissues, particularly skeletal muscle. Treatments to reduce hyperglycemia and
Stephen A Whelan et al.
The Journal of biological chemistry, 283(31), 21411-21417 (2008-06-04)
O-Linked beta-N-acetylglucosamine (O-GlcNAc) transferase (OGT) catalyzes the addition of O-linked beta-N-acetylglucosamine (O-GlcNAc) onto serine and threonine residues in response to stimuli or stress analogous to phosphorylation by Ser/Thr-kinases. Like protein phosphatases, OGT appears to be targeted to myriad specific substrates
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