J4250
JKC 302
≥97% (HPLC)
别名:
cyclo(D-Ser-Pro-D-Val-Leu-D-Trp)
方案
≥97% (HPLC)
储存温度
−20°C
SMILES字符串
CC(C)C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CO)NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC1=O)C(C)C
InChI
1S/C30H42N6O6/c1-16(2)12-21-26(38)32-22(13-18-14-31-20-9-6-5-8-19(18)20)27(39)34-23(15-37)30(42)36-11-7-10-24(36)28(40)35-25(17(3)4)29(41)33-21/h5-6,8-9,14,16-17,21-25,31,37H,7,10-13,15H2,1-4H3,(H,32,38)(H,33,41)(H,34,39)(H,35,40)/t21-,22+,23+,24-,25+/m0/s1
InChI key
FLVWONZBLRGQPK-VCDBXAJLSA-N
生化/生理作用
JKC-302 may be used as an endothelin receptor (eta) antagonist similar to JKC-301 and other cyclic D-amino acid containing pentapeptides.
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
L C Ngoka et al.
Journal of mass spectrometry : JMS, 35(2), 265-276 (2000-02-19)
We previously showed by using mass spectrometry that endothelin A selective receptor antagonists BQ123 and JKC301 form novel coordination compounds with sodium ions. This property may underlie the ability of an ET(A) antagonist to induce net tubular sodium reabsorption in
J E Tanus-Santos et al.
Anesthesia and analgesia, 90(1), 102-106 (2000-01-07)
Endothelin (ET) is involved in the humoral component of the vasoconstriction during pulmonary embolism. We examined the effects of selective ET receptor antagonists on the hemodynamic and respiratory changes and on serum thromboxane B2 (TXB2) levels, during a continuous venous
Daphne Merkus et al.
American journal of physiology. Heart and circulatory physiology, 288(5), H2088-H2092 (2005-01-08)
Alpha-adrenergic vasoconstriction in the coronary circulation is mediated through alpha-adrenoceptors on cardiac myocytes and subsequent release of endothelin, a very potent, long-lasting vasoconstrictor. Recent studies found that adult cardiac myocytes do not express the preproendothelin gene. Thus we hypothesized that
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持