J4250
JKC 302
≥97% (HPLC)
别名:
cyclo(D-Ser-Pro-D-Val-Leu-D-Trp)
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关于此项目
经验公式（希尔记法）:
C30H42N6O6
化学文摘社编号:
分子量:
582.69
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C30H42N6O6/c1-16(2)12-21-26(38)32-22(13-18-14-31-20-9-6-5-8-19(18)20)27(39)34-23(15-37)30(42)36-11-7-10-24(36)28(40)35-25(17(3)4)29(41)33-21/h5-6,8-9,14,16-17,21-25,31,37H,7,10-13,15H2,1-4H3,(H,32,38)(H,33,41)(H,34,39)(H,35,40)/t21-,22+,23+,24-,25+/m0/s1
SMILES string
CC(C)C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CO)NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC1=O)C(C)C
InChI key
FLVWONZBLRGQPK-VCDBXAJLSA-N
assay
≥97% (HPLC)
storage temp.
−20°C
Biochem/physiol Actions
JKC-302 may be used as an endothelin receptor (eta) antagonist similar to JKC-301 and other cyclic D-amino acid containing pentapeptides.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
J E Tanus-Santos et al.
Anesthesia and analgesia, 90(1), 102-106 (2000-01-07)
Endothelin (ET) is involved in the humoral component of the vasoconstriction during pulmonary embolism. We examined the effects of selective ET receptor antagonists on the hemodynamic and respiratory changes and on serum thromboxane B2 (TXB2) levels, during a continuous venous
L C Ngoka et al.
Journal of mass spectrometry : JMS, 35(2), 265-276 (2000-02-19)
We previously showed by using mass spectrometry that endothelin A selective receptor antagonists BQ123 and JKC301 form novel coordination compounds with sodium ions. This property may underlie the ability of an ET(A) antagonist to induce net tubular sodium reabsorption in
Daphne Merkus et al.
American journal of physiology. Heart and circulatory physiology, 288(5), H2088-H2092 (2005-01-08)
Alpha-adrenergic vasoconstriction in the coronary circulation is mediated through alpha-adrenoceptors on cardiac myocytes and subsequent release of endothelin, a very potent, long-lasting vasoconstrictor. Recent studies found that adult cardiac myocytes do not express the preproendothelin gene. Thus we hypothesized that
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