J4455
JSH-23
≥98% (HPLC), NF-kB nuclear translocation inhibitor, solid
别名:
4-甲基-N1-（3-苯基丙基）-1,2-苯二胺
产品名称
JSH-23, ≥98% (HPLC), solid
SMILES string
N(CCCc2ccccc2)c1c(cc(cc1)C)N
InChI
1S/C16H20N2/c1-13-9-10-16(15(17)12-13)18-11-5-8-14-6-3-2-4-7-14/h2-4,6-7,9-10,12,18H,5,8,11,17H2,1H3
InChI key
YMFNPBSZFWXMAD-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
storage condition
protect from light
color
off-white to gray-pink
solubility
DMSO: >10 mg/mL
shipped in
wet ice
storage temp.
−20°C
Quality Level
相关类别
Application
JSH-23 已被用作一种核因子 κB（NF-κB）p65 抑制剂。
Biochem/physiol Actions
JSH-23 是一种 NF-κB 核易位抑制剂。
JSH-23 是一种 NF-κB 核易位抑制剂。EMSA 和蛋白质印迹分析表明，它抑制 LPS 和细胞因子诱导的 NF-kB p65 亚基的核易位过程。该化合物具有适度的抑制活性（RAW 264.7 细胞中 IC50 值为 7.1 uM），但不影响 IkB 降解或恢复。该化合物以剂量依赖性方式抑制 LPS 诱导的细胞因子、COX2 和 iNOS 的表达，并且可能结合或干扰 p65 的和定位信号（NLS）。
Other Notes
光和空气敏感。
存储类别
11 - Combustible Solids
wgk
WGK 3
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Skin Sens. 1B
HMGB1 promotes the activation of NLRP3 and caspase-8 inflammasomes via NF-?B pathway in acute glaucoma.
Chi W et al.
Journal of Neuroinflammation, 12, 137-137 (2015)
Macrophage TCF-4 co-activates p65 to potentiate chronic inflammation and insulin resistance in mice.
Kang X et al.
Clinical Science (London, England : 1979), 130, 1257-1257 (2016)
L Shi et al.
Oncogene, 36(12), 1631-1643 (2016-11-22)
The coordination between cellular differentiation and the mesenchymal/stem transition is essential for both embryo development and neoplasia, suggesting a mechanistic link between these two major processes. In this work we show that miR-127, an embryo-expressing lung miRNA, was prominently induced
Macrophage TCF-4 co-activates p65 to potentiate chronic inflammation and insulin resistance in mice.
Xia Kang et al.
Clinical science (London, England : 1979), 130(14), 1257-1268 (2016-04-30)
Transcription factor 4 (TCF-4) was recently identified as a candidate gene for the cause of type 2 diabetes, although the mechanisms have not been fully elucidated. In the present study, we demonstrated that the TCF-4 transgene in macrophages aggravated high-fat diet
Meibao Feng et al.
Molecular cancer, 15(1), 77-77 (2016-12-04)
Lipocalin2 (LCN2) is a secretory protein that is aberrantly expressed in several types of cancer and has been involved in metastatic progression. However, neither mechanisms nor the role that LCN2 plays in the metastasis of colorectal cancer are clear. LCN2
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