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Merck
CN

J4829

Sigma-Aldrich

JFD00244

≥98% (HPLC), solid

别名:

1,4-bis[(p-hydroxyphenethyl)amino]-anthraquinone

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关于此项目

经验公式（希尔记法）:
C30H26N2O4
化学文摘社编号:
96969-83-4
分子量:
478.54
MDL编号:
MFCD00208443
UNSPSC代码:
12352202
PubChem化学物质编号:
329815737

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方案

≥98% (HPLC)

表单

solid

颜色

violet

溶解性

DMSO: ≥10 mg/mL
H2O: <2 mg/mL

储存温度

room temp

SMILES字符串

Oc1ccc(CCNc2ccc(NCCc3ccc(O)cc3)c4C(=O)c5ccccc5C(=O)c24)cc1

InChI

1S/C30H26N2O4/c33-21-9-5-19(6-10-21)15-17-31-25-13-14-26(32-18-16-20-7-11-22(34)12-8-20)28-27(25)29(35)23-3-1-2-4-24(23)30(28)36/h1-14,31-34H,15-18H2

InChI key

UUJHFIBEJJLZBF-UHFFFAOYSA-N

相关类别

生化/生理作用

JFD00244 is a SIRT (sirtuin, human silent information regulator) inhibitor.

特点和优势

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

象形图

Environment
GHS09

警示用语：

Warning

危险声明

H410

预防措施声明

P273 - P391 - P501

危险分类

Aquatic Acute 1 - Aquatic Chronic 1

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
069K4612
127K4614

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Anu J Tervo et al.
Journal of medicinal chemistry, 47(25), 6292-6298 (2004-11-30)
Type 2 human sirtuin (SIRT2) is a NAD(+)-dependent cytoplasmic protein that is colocalized with HDAC6 on microtubules. SIRT2 has been shown to deacetylate alpha-tubulin and to control mitotic exit in the cell cycle. To date, some small molecular inhibitors of
Anu J Tervo et al.
Journal of medicinal chemistry, 49(24), 7239-7241 (2006-11-28)
A successful virtual screening experiment of novel SIRT2 inhibitors is described. Four out of 11 experimentally tested compounds showed in vitro inhibitory activity toward SIRT2 in a micromolar level, resulting in an experimental hit ratio of 36%. Two of these

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