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Merck
CN

K0879

硫酸卡那霉素（来自卡那霉素链霉菌）

powder, γ-irradiated

别名:

卡那霉素 硫酸酯 来源于卡那霉素链霉菌, 卡那霉素 A, 卡那霉素碱 硫酸盐

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关于此项目

经验公式（希尔记法）:
C18H36N4O11 · H2O4S
化学文摘社编号:
25389-94-0
分子量:
582.58
NACRES:
NA.85
PubChem Substance ID:
57654313
UNSPSC Code:
12352200
EC Number:
246-933-9
MDL number:
MFCD00070253

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InChI key

OOYGSFOGFJDDHP-KMCOLRRFSA-N

InChI

1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1

SMILES string

OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O

biological source

Streptomyces kanamyceticus

grade

Molecular Biology

sterility

γ-irradiated

form

powder

potency

≥700 μg per mg

color

white to off-white

pH

6.5-8.5(1% solution)

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycoplasma

mode of action

protein synthesis | interferes

storage temp.

2-8°C

suitability

nonselective for Escherichia coli, nonselective for coliforms

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General description

Chemical structure: aminoglycoside
Kanamycin, A from Streptomyces kanamyceticus is a polycationic aminoglycoside and a broad-spectrum antibiotic. Structurally, it comprises hydroxyl and amino functional groups.

Application

Kanamycin sulfate Streptomyces kanamyceticus has been used as an antibiotic component in Murashige and Skoog medium for the selection of tobacco tissue culture explants. It has also been used as an antibiotic in Luria broth for culturing Escherichia coli K-12 strain MG1655 cells for secretion assay and E. coli TV1061 cells for immobilization studies.

Biochem/physiol Actions

作用机制：该产品通过与70S核糖体亚基结合，抑制易位并引起错误编码而起作用。

耐药机制：氨基糖苷类修饰酶（包括乙酰转移酶、磷酸转移酶、核苷酸转移酶）可以改变这种抗生素，阻止其与核糖体相互作用。

抗菌谱：硫酸卡那霉素对革兰氏阴性和革兰氏阳性菌以及支原体有效。
Kanamycin binds to the 30S ribosomal subunit and inhibits protein synthesis, leading to cell death.
Kanamycin′s hydroxyl and amino functional groups are crucial for its membrane action functionality. However, it also exhibits toxicity towards mammalian cells. It prevents contamination in cell culture as well as a selective agent for bacteria with kanamycin resistance.

Preparation Note

直接在小瓶中用无菌水配制储备液 (10mg/mL)。储备液应储存在 2-8°C 下。在 37°C 下可稳定 5 天。

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360D

Hazard Classifications

Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

新产品
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分析证书(COA)

Lot/Batch Number
107K8609
125K89091
125K8909
104H6726
101H6781

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Kevin M Krause et al.
Cold Spring Harbor perspectives in medicine, 6(6) (2016-06-03)
Aminoglycosides are natural or semisynthetic antibiotics derived from actinomycetes. They were among the first antibiotics to be introduced for routine clinical use and several examples have been approved for use in humans. They found widespread use as first-line agents in
Shoot Regenerative Capacity Assays in Arabidopsis and Tobacco
Tian-QiZ and Jia-Wei W
Bio-protocol, 6(5) (2016)
Torsten John et al.
Biochimica et biophysica acta. Biomembranes, 1859(11), 2242-2252 (2017-08-30)
Biological membranes are natural barriers to the transport of molecules and drugs within human bodies. Many antibacterial agents need to cross these membranes to reach their target and elicit specific effects. Kanamycin A belongs to the family of aminoglycoside antibiotics
Tim Axelrod et al.
Talanta, 149, 290-297 (2016-01-01)
Toxicants in water sources are of concern. We developed a tool that is affordable and easy-to-use for monitoring toxicity in water. It is a biosensor composed of disposable bioreporter pads (calcium alginate matrix with immobilized bacteria) and a non-disposable CMOS
Daejin Lim et al.
Frontiers in bioengineering and biotechnology, 8, 840-840 (2020-08-09)
Targeted delivery of drugs is a key aspect of the successful treatment of serious conditions such as tumors. In the pursuit of accurate delivery with high specificity and low size limit for peptide drugs, a synthetic type 3 secretion system
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