主要文件

查看所有文档

K1265

Ki8751 水合物

Name: Ki8751 水合物
Brand: SIGMA

≥98% (HPLC), solid

别名:

1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinolin-4-yloxy)-2-fluoro-phenyl]-urea 水合物

登录查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式（希尔记法）:

C₂₄H₁₈F₃N₃O₄ · xH₂O

化学文摘社编号:

228559-41-9

分子量:

469.41 (anhydrous basis)

UNSPSC Code:

12352200

MDL number:

MFCD09971092

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

属性

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: >20 mg/mL

storage temp.

−20°C

SMILES string

COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(F)c3)c2cc1OC

说明

Biochem/physiol Actions

Ki8751 is a potent, selective inhibitor of VEGFR-2 tyrosine kinase (IC₅₀= 0.9 nM).

pictograms

GHS07

signalword

Warning

hcodes

H315

Hazard Classifications

Skin Irrit. 2

存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

新产品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

117K4620

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas.

Kazuo Kubo et al.

Journal of medicinal chemistry, 48(5), 1359-1366 (2005-03-04)

N-Phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas were found to be a novel class of potent inhibitors for the vascular endothelial growth factor receptor 2 (VEGFR-2) tyrosine kinase through synthetic modifications of a lead compound and structure-activity relationship studies. A representative compound 6ab, termed Ki8751, inhibited