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K1751

酮洛芬

Name: 酮洛芬
Brand: SIGMA

≥98% (TLC), powder, non-steroidal anti-inflammatory compound

别名:

2-(3-苯甲酰苯基)丙酸

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关于此项目

经验公式（希尔记法）:

C₁₆H₁₄O₃

化学文摘社编号:

22071-15-4

分子量:

254.28

NACRES:

NA.77

PubChem Substance ID:

57654315

UNSPSC Code:

12352200

EC Number:

244-759-8

MDL number:

MFCD00055790

Assay:

≥98% (TLC)

Form:

powder

Quality level:

200

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属性

产品名称

酮洛芬, ≥98% (TLC)

biological source

synthetic

Quality Level

200

assay

≥98% (TLC)

form

powder

solubility

ethanol: 50 mg/mL, clear, colorless to yellow

originator

Bayer

SMILES string

CC(C(O)=O)c1cccc(c1)C(=O)c2ccccc2

InChI

1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)

InChI key

DKYWVDODHFEZIM-UHFFFAOYSA-N

Gene Information

human ... ALB(213), IL8RA(3577), PTGS1(5742), PTGS2(5743)

说明

General description

酮洛芬属于2-芳基丙酸类化合物。

Application

酮洛芬已被用于：

作为检测样品，通过色谱和显微技术分析长储存期的影响
作为非选择性COX抑制剂，在大鼠皮下注射，研究其对应激/盐酸甲基苯丙胺诱导的闭合蛋白、紧密连接蛋白-5和COX-2蛋白免疫反应性、β-营养不良聚糖的截短、脑水含量、以及异硫氰酸荧光素-葡聚糖外渗的变化的影响
在磷酸盐缓冲液中研究其抑制热诱导白蛋白变性的能力

Biochem/physiol Actions

它可作为治疗强直性脊柱炎、类风湿性关节炎和骨关节炎的有效药物。它还具有解热和镇痛作用。酮洛芬可防止前列腺素合成酶的作用。

非甾体类抗炎化合物，具有COX-1选择性。

Features and Benefits

该化合物由Bayer开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。

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pictograms

GHS06,GHS09

signalword

Danger

hcodes

H301,H315,H319,H400

pcodes

P264 - P273 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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全球贸易项目编号

货号	GTIN
K1751-5G	04061833868102
K1751-100G	04061833868089
K1751-1G	04061833868096
K1751-25G	04061832785547