K3000
激动素核苷
proapoptotic anitproliferative plant growth regulator
别名:
6-糠基氨基嘌呤核苷, N6-(2-呋喃甲基)腺苷, N6-糠基腺苷
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关于此项目
经验公式（希尔记法）:
C15H17N5O5
化学文摘社编号:
分子量:
347.33
NACRES:
NA.72
PubChem Substance ID:
UNSPSC Code:
12352207
EC Number:
224-389-3
MDL number:
Assay:
≥98% (HPLC), ≥98% (TLC)
Form:
powder
Solubility:
acetic acid: 49.00-51.00 mg/mL, clear, colorless to yellow
Storage temp.:
2-8°C
InChI key
CAGLGYNQQSIUGX-SDBHATRESA-N
InChI
1S/C15H17N5O5/c21-5-9-11(22)12(23)15(25-9)20-7-19-10-13(17-6-18-14(10)20)16-4-8-2-1-3-24-8/h1-3,6-7,9,11-12,15,21-23H,4-5H2,(H,16,17,18)/t9-,11-,12-,15-/m1/s1
SMILES string
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(NCc4ccco4)ncnc23
assay
≥98% (HPLC), ≥98% (TLC)
form
powder
solubility
acetic acid: 49.00-51.00 mg/mL, clear, colorless to yellow
storage temp.
2-8°C
Gene Information
rat ... Adora1(29290), Adora2a(25369), Adora3(25370)
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General description
Kinetin riboside is a ribosylated form of kinetin. It is a natural cytokinin plant hormone.
Application
Kinetin riboside may be used:
- to study its cytotoxic effects on plant and animal tumor cells
- to investigate its apoptotic effects in both cancer and immortalized cells
- to elucidate its influence on human prostate cell epithelial-mesenchymal transition in vitro
Biochem/physiol Actions
Kinetin riboside exhibits cytotoxic and antiproliferative activities. In addition, it also shows anticancer activity by inducing apoptosis in various types of cancers including myeloid leukemia cells, mouse melanoma B16F-10 cells, and plant tumor cells.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Yuki Ishii et al.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 13(1), 19-26 (2002-01-22)
We examined the effects of various adenine analogues on the growth and differentiation of human myeloid leukemia HL-60 cells. Some of these analogues inhibit growth and induce nitroblue tetrazolium reducing activity in HL-60 cells. Cytokinins such as kinetin, isopentenyladenine, and
Effects of kinetin riboside on proliferation and proapoptotic activities in human normal and cancer cell lines.
Dudzik P, Dulinska-Litewka J, Wyszko E, et al.
The Journal of Cell Biology, 112, 2115-2124 (2011)
Dennison Trinh et al.
Journal of neurochemistry, 156(6), 715-752 (2021-02-23)
Mitochondria are essential for neuronal function. They produce ATP to meet energy demands, regulate homeostasis of ion levels such as calcium and regulate reactive oxygen species that cause oxidative cellular stress. Mitochondria have also been shown to regulate protein synthesis
Bernard Griffaut et al.
International journal of biological macromolecules, 34(4), 271-275 (2004-09-18)
The cytotoxicity of two plant hormone compounds, kinetin and kinetin riboside, was studied on tumour cells, by colony forming assay with increased amount of cytotoxic molecules. The concentration of inhibitor required to reduce cell growth to 50% was determined for
Bo-Hwa Choi et al.
Cancer letters, 261(1), 37-45 (2007-12-29)
Here, we demonstrate that kinetin riboside (KR), a cytokinin analog, induces apoptosis in HeLa and mouse melanoma B16F-10 cells. KR disrupted the mitochondrial membrane potential and induced the release of cytochrome c and activation of caspase-3. Bad were upregulated while
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