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K3000

激动素核苷

Name: 激动素核苷
Brand: SIGMA

proapoptotic anitproliferative plant growth regulator

别名:

6-糠基氨基嘌呤核苷, N⁶-(2-呋喃甲基)腺苷, N⁶-糠基腺苷

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关于此项目

经验公式（希尔记法）:

C₁₅H₁₇N₅O₅

化学文摘社编号:

4338-47-0

分子量:

347.33

NACRES:

NA.72

PubChem Substance ID:

24896224

UNSPSC Code:

12352207

EC Number:

224-389-3

MDL number:

MFCD00037987

Assay:

≥98% (HPLC), ≥98% (TLC)

Form:

powder

Solubility:

acetic acid: 49.00-51.00 mg/mL, clear, colorless to yellow

Storage temp.:

2-8°C

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属性

assay

≥98% (HPLC), ≥98% (TLC)

form

powder

solubility

acetic acid: 49.00-51.00 mg/mL, clear, colorless to yellow

storage temp.

2-8°C

SMILES string

OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(NCc4ccco4)ncnc23

InChI

1S/C15H17N5O5/c21-5-9-11(22)12(23)15(25-9)20-7-19-10-13(17-6-18-14(10)20)16-4-8-2-1-3-24-8/h1-3,6-7,9,11-12,15,21-23H,4-5H2,(H,16,17,18)/t9-,11-,12-,15-/m1/s1

InChI key

CAGLGYNQQSIUGX-SDBHATRESA-N

Gene Information

rat ... Adora1(29290), Adora2a(25369), Adora3(25370)

说明

General description

Kinetin riboside is a ribosylated form of kinetin. It is a natural cytokinin plant hormone.

Application

Kinetin riboside may be used:

to study its cytotoxic effects on plant and animal tumor cells
to investigate its apoptotic effects in both cancer and immortalized cells
to elucidate its influence on human prostate cell epithelial-mesenchymal transition in vitro

Biochem/physiol Actions

Kinetin riboside exhibits cytotoxic and antiproliferative activities. In addition, it also shows anticancer activity by inducing apoptosis in various types of cancers including myeloid leukemia cells, mouse melanoma B16F-10 cells, and plant tumor cells.

存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Control of differentiation and apoptosis of human myeloid leukemia cells by cytokinins and cytokinin nucleosides, plant redifferentiation-inducing hormones.

Yuki Ishii et al.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 13(1), 19-26 (2002-01-22)

We examined the effects of various adenine analogues on the growth and differentiation of human myeloid leukemia HL-60 cells. Some of these analogues inhibit growth and induce nitroblue tetrazolium reducing activity in HL-60 cells. Cytokinins such as kinetin, isopentenyladenine, and

The multi-faceted role of mitochondria in the pathology of Parkinson's disease.

Dennison Trinh et al.

Journal of neurochemistry, 156(6), 715-752 (2021-02-23)

Mitochondria are essential for neuronal function. They produce ATP to meet energy demands, regulate homeostasis of ion levels such as calcium and regulate reactive oxygen species that cause oxidative cellular stress. Mitochondria have also been shown to regulate protein synthesis

Effects of kinetin riboside on proliferation and proapoptotic activities in human normal and cancer cell lines.

Dudzik P, Dulinska-Litewka J, Wyszko E, et al.

The Journal of Cell Biology, 112, 2115-2124 (2011)

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全球贸易项目编号

货号	GTIN
K3000-5G	04061833868393
K3000-100G	04061833697900