Name: 拉米夫定
Brand: SIGMA

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About This Item

经验公式（希尔记法）:

C₈H₁₁N₃O₃S

CAS Number:

134678-17-4

分子量:

229.26

MDL编号:

MFCD00869739

UNSPSC代码:

12352200

PubChem化学物质编号:

329817388

NACRES:

NA.77

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Product Name

拉米夫定, ≥98% (HPLC), powder

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

water: 10 mg/mL, clear

创始人

GlaxoSmithKline

储存温度

room temp

SMILES字符串

NC1=NC(=O)N(C=C1)[C@@H]2CS[C@H](CO)O2

InChI

1S/C8H11N3O3S/c9-5-1-2-11(8(13)10-5)6-4-15-7(3-12)14-6/h1-2,6-7,12H,3-4H2,(H2,9,10,13)/t6-,7+/m0/s1

InChI key

JTEGQNOMFQHVDC-NKWVEPMBSA-N

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应用

Lamivudine has been used to deplete the Hepatitis B Virus (HBV) covalently closed circular DNA (cccDNA) forms for the preparation of inverse nested PCR.

生化/生理作用

拉米夫定是一种有效的核苷类似物逆转录酶抑制剂（nRTI）。

拉米夫定是一种有效的核苷类似物逆转录酶抑制剂（nRTI）。它是胞苷的类似物，除抑制乙型肝炎的逆转录酶外，还可抑制两种类型（1型和2型）的HIV逆转录酶。它需要磷酸化为其三磷酸形式才具有活性。3TC-三磷酸也抑制细胞DNA聚合酶。

特点和优势

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.