L137
L-733,060 hydrochloride
solid, ≥98% (HPLC)
别名:
(2S,3S)-3-[(3,5-bis(Trifluoromethyl)phenyl)methoxy]-2-phenylpiperidine hydrochloride
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关于此项目
经验公式（希尔记法）:
C20H19F6NO · HCl
化学文摘社编号:
分子量:
439.82
UNSPSC Code:
12352202
PubChem Substance ID:
MDL number:
SMILES string
Cl[H].FC(F)(F)c1cc(CO[C@@H]2CCCN[C@@H]2c3ccccc3)cc(c1)C(F)(F)F
assay
≥98% (HPLC)
form
solid
color
white
solubility
DMSO: >10 mg/mL, H2O: insoluble
storage temp.
2-8°C
Gene Information
human ... TACR1(6869)
Biochem/physiol Actions
Non-peptide NK1 tachykinin receptor antagonist; selective for guinea pig/human versus rat/mouse. Micromolar concentrations of L-733,060 inhibit the growth of human gastric and colon adenocarcinomas.in a dose-dependent manner, eventually leading to apoptosis in both cell lines.
Legal Information
Manufactured and sold under license from Merck & Co., Inc., Kenilworth, NJ, U.S.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
P Kiatpapan et al.
Journal of bioscience and bioengineering, 92(5), 459-465 (2005-10-20)
To develop systems for the expression of heterologous genes in probiotic strains of Lactobacillus and Propionibacterium, we used Lactobacillus plantarum and Propionibacterium freudenreichii and a modified gene encoding cholesterol oxidase (choA) from Streptomyces sp. to generate working models. The acetyl
Jong-Hyun Kim et al.
Journal of bioscience and bioengineering, 107(2), 124-129 (2009-02-17)
A gene (apuA) encoding amylopullulanase from a starch-hydrolyzing lactic acid bacterium, Lactobacillus plantarum L137, which had been isolated from traditional fermented food made from fish and rice in the Philippines, was found to contain two unique amino acid repeating units
Y Kaneko et al.
Journal of bioscience and bioengineering, 89(1), 62-67 (2005-10-20)
Lactobacillus plantarum NC13, a strain derived from the L. plantarum strain L137 isolated from a traditional fermented food produced in the Philippines, contains 9 of the 15 plasmids in the parental strain. To construct a shuttle vector between L. plantarum
Jitka Myskova et al.
Journal of medical entomology, 45(1), 133-138 (2008-02-21)
Quantification of Leishmania parasites in the sand fly digestive tract is important for evaluation of vector competence. We compared quantitative polymerase chain reaction (Q-PCR) with two "traditional" methods, estimation in situ and direct counting with the aid of a hemocytometer
Marisa Rosso et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 29(4), 245-254 (2008-09-11)
It has been demonstrated that substance P (SP) and neurokinin-1 (NK-1) receptor antagonist L-733,060 induces cell proliferation and inhibition, respectively, in several human cancer cell lines. At present, it is unknown whether such actions are exerted on human gastric and
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