L1636
L-Leucine chloromethyl ketone hydrochloride
别名:
Leu-CMK HCl
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关于此项目
经验公式（希尔记法）:
C7H14ClNO · HCl
化学文摘社编号:
分子量:
200.11
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
表单
powder
颜色
white to off-white
SMILES字符串
Cl.CC(C)C[C@H](N)C(=O)CCl
InChI
1S/C7H14ClNO.ClH/c1-5(2)3-6(9)7(10)4-8;/h5-6H,3-4,9H2,1-2H3;1H/t6-;/m0./s1
InChI key
DRZZRBOLWKRHPF-RGMNGODLSA-N
生化/生理作用
L-Leucine chloromethyl ketone (Leu-CMK) is used as a lysosomal cysteine protease inhibitor and as an insulin-like stimulator of lipid synthesis. L-Leucine chloromethyl ketone (Leu-CMK) may be acetylated to generate acetylleucine chloromethyl ketone, an inhibitor of acylpeptide hydrolase.
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
M J Lee et al.
Archives of insect biochemistry and physiology, 39(1), 9-17 (1998-11-17)
N alpha-tosyl-L-lysine chloromethyl ketone (TLCK) stimulates lipid synthesis in locust fat body in vitro, and is able to reverse the inhibitory effects of AKH-I on lipid synthesis. Effective stimulatory concentrations of TLCK were in the range of 0.2-1.0 mM. Similar
R H Matthews et al.
Biochimica et biophysica acta, 601(3), 640-653 (1980-10-02)
Alanine chloromethylketone and leucine chloromethylketone were synthesized and their effects on amino acid transport in sarcoma 37 mirone ascites tumor (S37) cells were studied. Alanine chloromethylketone preincubation weakly inhibited system A. Leucine chloromethylketone preincubation strongly inhibited both amino acid transport
R H Matthews et al.
Cancer letters, 16(2), 207-218 (1982-07-01)
Leucine chloromethylketone labeling of viable S37 cells was preferential for the plasma membrane fraction. The pattern of radiolabeling of the plasma membrane proteins was time dependent. After 5 min the radiolabel was localized with glutamyl transpeptidase, and subsequently with other
Y Tanaka et al.
Xenobiotica; the fate of foreign compounds in biological systems, 29(3), 281-295 (1999-04-29)
1. The degradation of recombinant human insulin-like growth factor-I (rhIGF-I) by purified lysosomes of rat kidney was examined in vitro. The peptide structures of the 13 degradation products were deduced from the sequence analysis and the molecular mass. Rat kidney
M Yamaguchi et al.
Biochemical and biophysical research communications, 263(1), 139-142 (1999-09-16)
Acetylleucine chloromethyl ketone (ALCK), an inhibitor of acylpeptide hydrolase (ACPH), inhibited the growth of human monoblastic U937 cells in a dose- and time-dependent manner. Morphology of the ALCK-exposed cells showed typical apoptosis, judging from the nuclear condensation and segmentation. Chromosomal
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