L2139
低密度脂蛋白 来源于人类血浆
buffered aqueous solution, from human plasma
别名:
β-脂蛋白, LDL, 低密度脂蛋白
生物来源
human plasma
无菌性
0.22 μm filtered
表单
buffered aqueous solution
运输
wet ice
储存温度
2-8°C
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一般描述
低密度脂蛋白比VLDL和IDL（26nm）（MW大约3.5百万）分子质量小，而且更稠密 (~1.04)。LDL蛋白质组分是载脂蛋白 B100。LDL含有20-22%蛋白质，10-15%甘油三酯，20-28%磷酸酯，37-48%胆固醇脂和8-10%胆固醇。
生化/生理作用
LDL和HDL负责在血浆中运输饮食和内源胆固醇。LDL是胆固醇和胆固醇脂的主要载体，组成了血浆中总脂蛋白的一半以上。LD通过受体介导内吞作用，被肝脏和其他组织吸收。LDL受体的胞浆结构域帮助形成被小窝，膜上的受体富集区域。受体配体结合域识别LDL上的 apo-B100，导致包被网格蛋白的囊泡形成。ATP依赖质子泵减低囊泡内的pH，导致LDL从它的受体上脱离。当网格蛋白囊泡和溶菌酶融合丧失，会导致多肽和胆固醇脂酶水解。LDL受体会循环至细胞膜。胰岛素，三碘甲状腺原氨酸和地塞米松被证明参与调解LDL受体介导的摄入。
包装
Package size based on protein content
外形
Solution in 0.15 M NaCl with 0.01% EDTA, pH 7.4
免责声明
Freezing may cause denaturation.
法规信息
新产品
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The Journal of experimental medicine, 180(3), 851-860 (1994-09-01)
Normal human bone marrow cells, highly enriched for burst-forming units-erythroid (BFU-E), were cultured in serum-free medium, in the presence and absence of various factors, to investigate the mechanisms involved in regulating erythroid differentiation. In cultures containing interleukin 3 (IL-3), Steel
Douglas C Dooley et al.
Methods in molecular biology (Clifton, N.J.), 263, 201-218 (2004-02-21)
Methods are described for the characterization of CD34 antigen modulation and its relationship to cell proliferation in early human hematopoietic cells. Toward that end, quiescent primitive CD34+ and CD34NEG cells are purified from mobilized peripheral blood (MoPB). Unlike CD34NEG cells
H Vink et al.
Circulation, 101(13), 1500-1502 (2000-04-04)
Flowing erythrocytes and platelets are separated from the luminal endothelial cell (EC) surface by a 0.5-microm-wide space named the endothelial surface layer. We hypothesized that the disruption of the endothelial surface layer by oxidized low-density lipoproteins (Ox-LDL) contributes to atherogenic
Alina A Constantinescu et al.
Arteriosclerosis, thrombosis, and vascular biology, 23(9), 1541-1547 (2003-07-12)
A thick endothelial glycocalyx provides the endothelial surface with a nonadherent shield. Oxidized LDL (Ox-LDL) degrades the endothelial glycocalyx. We hypothesized that glycocalyx degradation stimulates leukocyte-endothelial cell adhesion, whereas intravascular supplementation with sulfated polysaccharides reconstitutes the endothelial glycocalyx and attenuates
Murat O Arcasoy et al.
British journal of haematology, 130(1), 121-129 (2005-06-29)
The regeneration of circulating red blood cells in response to anaemia associated with blood loss or haemolysis involves an increased rate of erythropoiesis and expansion of proerythroblasts, the bone marrow precursor cells that terminally differentiate into mature erythrocytes. This study
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