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L2167

L-165,041

Name: L-165,041
Brand: SIGMA

≥98% (HPLC), powder

别名:

4-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxyacetic acid

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关于此项目

经验公式（希尔记法）:

C₂₂H₂₆O₇

化学文摘社编号:

79558-09-1

分子量:

402.44

NACRES:

NA.77

PubChem Substance ID:

24278477

UNSPSC Code:

12352200

MDL number:

MFCD04974501

Assay:

≥98% (HPLC)

Form:

powder

Storage condition:

protect from light, under inert gas

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属性

Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

protect from light, under inert gas

color

off-white

mp

127-128 °C (lit.)

solubility

DMSO: >10 mg/mL

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

CCCc1c(O)c(ccc1OCCCOc2ccc(OCC(O)=O)cc2)C(C)=O

InChI

1S/C22H26O7/c1-3-5-19-20(11-10-18(15(2)23)22(19)26)28-13-4-12-27-16-6-8-17(9-7-16)29-14-21(24)25/h6-11,26H,3-5,12-14H2,1-2H3,(H,24,25)

InChI key

HBBVCKCCQCQCTJ-UHFFFAOYSA-N

Gene Information

human ... PPARD(5467)

说明

Application

L-165,041 has been used as a peroxisome proliferator-activated receptor β/δ (PPARβ/δ) ligand to study its influence on PPARβ/δ mediated postnatal myogenesis in C2C12 myoblasts.

Biochem/physiol Actions

L-165041 dose-dependently blocks rat vascular smooth muscle cell (VSMC) proliferation and migration by inducing the cell cycle arrest. It has the potential to treat pathological cardiovascular conditions, such as restenosis and atherosclerosis. L-165041 also effectively inhibits the progression of diabetic nephropathy. It exhibits anti-apoptosis and anti-angiogenic effects.

PPARβ (PPARδ) selective agonist.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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存储类别

11 - Combustible Solids

怎么回事？

WGK 3

闪点 (F)

Not applicable

闪点 (°C)