L2776
Lys-Gln-Ala-Gly-Asp-Val
≥97% (HPLC)
别名:
KQAGDV
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关于此项目
经验公式（希尔记法）:
C25H44N8O10
化学文摘社编号:
分子量:
616.66
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C25H44N8O10/c1-12(2)20(25(42)43)33-24(41)16(10-19(36)37)31-18(35)11-29-21(38)13(3)30-23(40)15(7-8-17(28)34)32-22(39)14(27)6-4-5-9-26/h12-16,20H,4-11,26-27H2,1-3H3,(H2,28,34)(H,29,38)(H,30,40)(H,31,35)(H,32,39)(H,33,41)(H,36,37)(H,42,43)
SMILES string
CC(C)C(NC(=O)C(CC(O)=O)NC(=O)CNC(=O)C(C)NC(=O)C(CCC(N)=O)NC(=O)C(N)CCCCN)C(O)=O
InChI key
AFAFFVKJJYBBTC-UHFFFAOYSA-N
assay
≥97% (HPLC)
form
powder
technique(s)
LC/MS: suitable
color
white to off-white
storage temp.
−20°C
Biochem/physiol Actions
Lys-Gln-Ala-Gly-Asp-Val (KQAGDV) is a cell adhesion peptide used to study adhesion of platelets to neutrophils via the integrin glycoproteins gpIIb/IIIa.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
T K Gartner et al.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 198(1), 649-655 (1991-10-01)
Antiplatelet agents are clinically useful as antithrombotic entities. The importance of antiplatelet agents led us to design, synthesize, and characterize a new antiplatelet peptide. This peptide is a presumptive mimic of a ligand binding site on the platelet fibrinogen receptor.
Bernard Chabannes et al.
British journal of haematology, 121(2), 341-348 (2003-04-16)
Polymorphonuclear leucocytes and blood platelets co-operate in several pathophysiological processes, and arachidonic acid (AA) metabolites produced in response to the activation of these cells are potent mediators of their functions. We studied the role of platelets in the formation of
Brenda K Mann et al.
Journal of biomedical materials research, 60(1), 86-93 (2002-02-09)
The effects of cell adhesion peptides (RGDS, KQAGDV, VAPG) on vascular smooth muscle cells grown on modified surfaces and in tissue-engineering scaffolds were examined. Cells were more strongly adhered to surfaces modified with adhesive ligands than to control surfaces (no
Integrins.
E Ruoslahti
The Journal of clinical investigation, 87(1), 1-5 (1991-01-01)
Roy R Hantgan et al.
Protein science : a publication of the Protein Society, 15(8), 1893-1906 (2006-08-01)
This study tested the hypothesis that high-affinity binding of macromolecular ligands to the alphaIIbbeta3 integrin is tightly coupled to binding-site remodeling, an induced-fit process that shifts a conformational equilibrium from a resting toward an open receptor. Interactions between alphaIIbbeta3 and
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