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Merck
CN

L2776

Lys-Gln-Ala-Gly-Asp-Val

≥97% (HPLC)

别名:

KQAGDV

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关于此项目

经验公式(希尔记法):
C25H44N8O10
化学文摘社编号:
分子量:
616.66
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
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assay

≥97% (HPLC)

form

powder

technique(s)

LC/MS: suitable

color

white to off-white

storage temp.

−20°C

SMILES string

CC(C)C(NC(=O)C(CC(O)=O)NC(=O)CNC(=O)C(C)NC(=O)C(CCC(N)=O)NC(=O)C(N)CCCCN)C(O)=O

InChI

1S/C25H44N8O10/c1-12(2)20(25(42)43)33-24(41)16(10-19(36)37)31-18(35)11-29-21(38)13(3)30-23(40)15(7-8-17(28)34)32-22(39)14(27)6-4-5-9-26/h12-16,20H,4-11,26-27H2,1-3H3,(H2,28,34)(H,29,38)(H,30,40)(H,31,35)(H,32,39)(H,33,41)(H,36,37)(H,42,43)

InChI key

AFAFFVKJJYBBTC-UHFFFAOYSA-N

Biochem/physiol Actions

Lys-Gln-Ala-Gly-Asp-Val (KQAGDV) is a cell adhesion peptide used to study adhesion of platelets to neutrophils via the integrin glycoproteins gpIIb/IIIa.


存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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Brenda K Mann et al.
Journal of biomedical materials research, 60(1), 86-93 (2002-02-09)
The effects of cell adhesion peptides (RGDS, KQAGDV, VAPG) on vascular smooth muscle cells grown on modified surfaces and in tissue-engineering scaffolds were examined. Cells were more strongly adhered to surfaces modified with adhesive ligands than to control surfaces (no
Bernard Chabannes et al.
British journal of haematology, 121(2), 341-348 (2003-04-16)
Polymorphonuclear leucocytes and blood platelets co-operate in several pathophysiological processes, and arachidonic acid (AA) metabolites produced in response to the activation of these cells are potent mediators of their functions. We studied the role of platelets in the formation of
T K Gartner et al.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 198(1), 649-655 (1991-10-01)
Antiplatelet agents are clinically useful as antithrombotic entities. The importance of antiplatelet agents led us to design, synthesize, and characterize a new antiplatelet peptide. This peptide is a presumptive mimic of a ligand binding site on the platelet fibrinogen receptor.



全球贸易项目编号

货号GTIN
L2776-1MG04061826284872