L2776
Lys-Gln-Ala-Gly-Asp-Val
≥97% (HPLC)
别名:
KQAGDV
方案
≥97% (HPLC)
表单
powder
技术
LC/MS: suitable
颜色
white to off-white
储存温度
−20°C
SMILES字符串
CC(C)C(NC(=O)C(CC(O)=O)NC(=O)CNC(=O)C(C)NC(=O)C(CCC(N)=O)NC(=O)C(N)CCCCN)C(O)=O
InChI
1S/C25H44N8O10/c1-12(2)20(25(42)43)33-24(41)16(10-19(36)37)31-18(35)11-29-21(38)13(3)30-23(40)15(7-8-17(28)34)32-22(39)14(27)6-4-5-9-26/h12-16,20H,4-11,26-27H2,1-3H3,(H2,28,34)(H,29,38)(H,30,40)(H,31,35)(H,32,39)(H,33,41)(H,36,37)(H,42,43)
InChI key
AFAFFVKJJYBBTC-UHFFFAOYSA-N
Amino Acid Sequence
Lys-Gln-Ala-Gly-Asp-Val
生化/生理作用
Lys-Gln-Ala-Gly-Asp-Val (KQAGDV) is a cell adhesion peptide used to study adhesion of platelets to neutrophils via the integrin glycoproteins gpIIb/IIIa.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Bernard Chabannes et al.
British journal of haematology, 121(2), 341-348 (2003-04-16)
Polymorphonuclear leucocytes and blood platelets co-operate in several pathophysiological processes, and arachidonic acid (AA) metabolites produced in response to the activation of these cells are potent mediators of their functions. We studied the role of platelets in the formation of
Brenda K Mann et al.
Journal of biomedical materials research, 60(1), 86-93 (2002-02-09)
The effects of cell adhesion peptides (RGDS, KQAGDV, VAPG) on vascular smooth muscle cells grown on modified surfaces and in tissue-engineering scaffolds were examined. Cells were more strongly adhered to surfaces modified with adhesive ligands than to control surfaces (no
T K Gartner et al.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 198(1), 649-655 (1991-10-01)
Antiplatelet agents are clinically useful as antithrombotic entities. The importance of antiplatelet agents led us to design, synthesize, and characterize a new antiplatelet peptide. This peptide is a presumptive mimic of a ligand binding site on the platelet fibrinogen receptor.
Integrins.
E Ruoslahti
The Journal of clinical investigation, 87(1), 1-5 (1991-01-01)
Roy R Hantgan et al.
Protein science : a publication of the Protein Society, 15(8), 1893-1906 (2006-08-01)
This study tested the hypothesis that high-affinity binding of macromolecular ligands to the alphaIIbbeta3 integrin is tightly coupled to binding-site remodeling, an induced-fit process that shifts a conformational equilibrium from a resting toward an open receptor. Interactions between alphaIIbbeta3 and
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