L3669
LPK-26
≥98% (HPLC), powder
别名:
2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(2-isopropyl)-2-(1-(3-pyrrolinyl))ethyl]acetamide hydrochloride
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关于此项目
经验公式（希尔记法）:
C18H24Cl2N2O · HCl
化学文摘社编号:
分子量:
391.76
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI key
WOOCHAFXTYNYQE-UNTBIKODSA-N
SMILES string
Cl.CC(C)[C@@H](CN1CC=CC1)N(C)C(=O)Cc2ccc(Cl)c(Cl)c2
InChI
1S/C18H24Cl2N2O.ClH/c1-13(2)17(12-22-8-4-5-9-22)21(3)18(23)11-14-6-7-15(19)16(20)10-14;/h4-7,10,13,17H,8-9,11-12H2,1-3H3;1H/t17-;/m1./s1
assay
≥98% (HPLC)
form
powder
color
off-white
solubility
H2O: >10 mg/mL
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
LPK-26 is a potent, selective kappa opioid receptor agonist and an antinociceptive, devoid physical dependence properties.
LPK-26 is an analog of ICI-199441 and (-)U50,488H (classic kappa agonists). It has extremely high kappa affinity (0.64 nM) and low mu and delta receptor affnities (1170 and 10,000nM). LPK-26 produces an antinocicpetive effect with much higher potency in vivo than morphine or U50488. LPK-26 does not produce physical dependence in mice, but it does suppress naloxone-induced behavioral effects in mice treated with morphine.
Features and Benefits
This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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