L4886
白三烯C4
≥92.5% (HPLC), 45-70 μg/mL in methanol
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经验公式（希尔记法）:
C30H47N3O9S
化学文摘社编号:
分子量:
625.77
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
200-659-6
MDL number:
InChI key
GWNVDXQDILPJIG-KVUXNHQJSA-N
InChI
1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/b7-6+,10-9+,12-11+,16-13+
SMILES string
OC(CCCC(O)=O)C(SCC(NC(CCC(C(O)=O)N)=O)C(NCC(O)=O)=O)/C=C/C=C/C=C\C/C=C\CCCCC
assay
≥92.5% (HPLC)
concentration
45-70 μg/mL in methanol
shipped in
dry ice
storage temp.
−20°C
Biochem/physiol Actions
Leukotriene formed from the conjugation of LTA4 with glutathione. Induces bronchoconstriction and renal vasoconstriction.
Packaging
在氩气下包装。
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
target_organs
Eyes
存储类别
3 - Flammable liquids
wgk
WGK 2
flash_point_f
49.5 °F - closed cup
flash_point_c
9.7 °C - closed cup
法规信息
新产品
此项目有
Evan S Dellon et al.
The American journal of gastroenterology, 107(10), 1503-1511 (2012-07-11)
Features of eosinophilic esophagitis (EoE) and gastroesophageal reflux disease (GERD) overlap. We aimed to determine whether staining for tissue biomarkers would differentiate EoE from GERD, suggesting utility for diagnosis of EoE. In this case-control study, EoE patients defined by consensus
B Samuelsson
Science (New York, N.Y.), 220(4597), 568-575 (1983-05-06)
Arachidonic acid plays a central role in a biological control system where such oxygenated derivatives as prostaglandins, thromboxanes, and leukotrienes are mediators. The leukotrienes are formed by transformation of arachidonic acid into an unstable epoxide intermediate, leukotriene A4, which can
J Maclouf et al.
Haemostasis, 26 Suppl 4, 28-36 (1996-10-01)
Formation of eicosanoids is a special mode of cell communication whereby production of eicosanoids by mixed cell populations differs from that expected from each individual cell. Transcellular biosynthesis of leukotriene C4 occurs via transfer of the reactive intermediate leukotriene A4
Donald W Macglashan et al.
The Journal of allergy and clinical immunology, 132(4), 906-911 (2013-06-25)
Treatment of allergic patients with omalizumab results in a paradoxical increase in their basophil histamine release (HR) response ex vivo to cross-linking anti-IgE antibody. It is not known whether this change in response is associated with an increase in intrinsic cellular
Rikiya Koketsu et al.
International archives of allergy and immunology, 161 Suppl 2, 23-31 (2013-06-05)
Basophils and mast cells are important initiator/effector cells capable of rapidly responding to IgE-mediated stimulation, but the precise mechanisms regulating their functions in vivo have not been fully identified. In this study, we assessed whether low levels of antigen can
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